{"product_id":"recombinant-human-pth1r-protein-gly49-his-tag-pksh032853","title":"Recombinant Human PTH1R Protein (Gly49, His Tag) - PKSH032853","description":"\u003cp\u003eRecombinant Human PTH1R Protein (Gly49, His Tag)\u003c\/p\u003e\n\n\u003cp\u003eSizes: 10μg, 50μg\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: PKSH032853-10, PKSH032853-50\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eAbbreviation: PTH1R\u003c\/p\u003e\n\n\u003cp\u003eTarget Synonym: Parathyroid hormone\/parathyroid hormone-related peptide receptor; PTH\/PTHrP type I receptor; PTH\/PTHr receptor; Parathyroid hormone 1 receptor; PTH1 receptor; PTH1R\u003c\/p\u003e\n\n\u003cp\u003eUNIProt ID: Q0VGD7\u003c\/p\u003e\n\n\u003cp\u003eTarget Species: Human\u003c\/p\u003e\n\n\u003cp\u003eExpression Host: HEK293 Cells\u003c\/p\u003e\n\n\u003cp\u003eFusion Tag: C-6His\u003c\/p\u003e\n\n\u003cp\u003eAccession: Q0VGD7\u003c\/p\u003e\n\n\u003cp\u003eBackground: Parathyroid hormone 1 receptor(PTH1R) is a multi-pass membrane protein. The protein is expressed in high levels in bone and kidney and regulates calcium ionhomeostasis through activation of adenylate cyclase and phospholipase C. In bone, it is expressed on the surface of osteoblasts. When the receptor is activated through PTH binding, osteoblasts express RANKL (Receptor Activator of Nuclear Factor kB Ligand), which binds to RANK (Receptor Activator of Nuclear Factor kB) on osteoclasts. This turns on osteoclasts to ultimately increase the resorption rate.\u003c\/p\u003e\n\n\u003cp\u003eSequence: Tyr23-Met 189\u003c\/p\u003e\n\n\u003cp\u003ePurity: \u0026gt; 95 % as determined by reducing SDS-PAGE.\u003c\/p\u003e\n\n\u003cp\u003eFormulation: Lyophilized from a 0.2 μm filtered solution of PBS, pH7.4.\u003cbr\u003e\nNormally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.\u003cbr\u003e\nPlease refer to the specific buffer information in the printed manual.\u003c\/p\u003e\n\n\u003cp\u003eReconstitution: Please refer to the printed manual for detailed information.\u003c\/p\u003e\n\n\u003cp\u003eEndotoxin: \u0026lt; 1.0 EU per μg of the protein as determined by the LAL method.\u003c\/p\u003e\n\n\u003cp\u003eCalculated MW: 20.2 kDa\u003c\/p\u003e\n\n\u003cp\u003eObserved MW: 30 kDa\u003c\/p\u003e\n\n\u003cp\u003eStorage: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at \u0026lt; -20℃ for 3 months.\u003c\/p\u003e\n\n\u003cp\u003eShipping: This product is provided as lyophilized powder which is shipped with ice packs.\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"Elabscience","offers":[{"title":"10μg","offer_id":43149116571827,"sku":"PKSH032853-10","price":163.8,"currency_code":"CAD","in_stock":true},{"title":"50μg","offer_id":43149116604595,"sku":"PKSH032853-50","price":415.8,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/products\/logo_new_3983e841-2699-4b58-9fe0-953f4ee17bc5.png?v=1710340929","url":"https:\/\/afsbio.com\/products\/recombinant-human-pth1r-protein-gly49-his-tag-pksh032853","provider":"AFSBio Inc.","version":"1.0","type":"link"}