{"product_id":"recombinant-human-r-spondin-2-rspo2-protein-rp03266","title":"Recombinant Human R-spondin-2\/RSPO2 Protein - RP03266","description":"\u003cp\u003eRecombinant Human R-spondin-2\/RSPO2 Protein\u003c\/p\u003e\n\n\u003cp\u003eSizes: 20ug, 50ug, 100ug\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: RP03266-20, RP03266-50, RP03266-100\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eDescription: Recombinant Human R-spondin-2\/RSPO2 Protein is produced by Mammalian expression system. The target protein is expressed with sequence (Ala32-Gly205) of human R-spondin-2 (Accession #Q6UXX9) fused with hFc tag at the C-terminus.\u003c\/p\u003e\n\n\u003cp\u003eAlternate Names: R-spondin-2, Roof plate-specific spondin-2, hRspo2, RSPO2, UNQ9384\/PRO34209\u003c\/p\u003e\n\n\u003cp\u003eSWISS: Q6UXX9-1\u003c\/p\u003e\n\n\u003cp\u003eGeneID: 340419\u003c\/p\u003e\n\n\u003cp\u003eSpecies: Human\u003c\/p\u003e\n\n\u003cp\u003ePurity: ≥ 90 % as determined by SDS-PAGE.\u003c\/p\u003e\n\n\u003cp\u003eStorage: Store at -20℃. Store the lyophilized protein at -20℃ to -80 ℃ up to 1 year from the date of receipt. After reconstitution, the protein solution is stable at -20℃ for 3 months, at 2-8℃ for up to 1 week.\u003c\/p\u003e\n\n\u003cp\u003eBackground: R-spondins are secretory proteins localized in the endoplasmic reticulum and Golgi bodies and are processed through the secretory pathway. The RSPO family comprises four proteins, i.e., R-spondin 1-4, which are important secreted regulators of the Wnt\/尾-catenin and Wnt\/PCP signaling pathway and govern various functions and are involved in vital cellular processes such as stem cell renewal, morphogenesis and, tumorigenesis. Among the R-spondin family, R-spondin-2, is a key protein that regulates ligand-dependent 尾-catenin signaling. And it has been reported to play a pivotal role in myogenesis, osteoblast differentiation, and limb specification during embryonic development.\u003c\/p\u003e\n\n\u003cp\u003eBio-Activity: Measured by its ability to induce Topflash reporter activity in HEK293T human embryonic kidney cells. The ED50 for this effect is 0.72-2.88 ng\/mL in the presence of 5 ng\/mL Recombinant Mouse Wnt-3a,corresponding to a specific activity of 3.47×10^5 ~1.39×10^6 units\/mg.\u003c\/p\u003e\n\n\u003cp\u003eSource: HEK293 cells\u003c\/p\u003e\n\n\u003cp\u003eTag: C-hFC\u003c\/p\u003e\n\n\u003cp\u003eFormulation: Lyophilized from a 0.22 μm filtered solution of PBS, pH 7.4.\u003c\/p\u003e\n\n\u003cp\u003eAntigen Sequence: ASYVSNPICKGCLSCSKDNGCSRCQQKLFFFLRREGMRQYGECLHSCPSGYYGHRAPDMNRCARCRIENCDSCFSKDFCTKCKVGFYLHRGRCFDECPDGFAPLEETMECVEGCEVGHWSEWGTCSRNNRTCGFKWGLETRTRQIVKKPVKDTILCPTIAESRRCKMTMRHCPG\u003c\/p\u003e\n\n\u003cp\u003eEndotoxin: \u0026lt; 0.01 EU\/μg of the protein by LAL method\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"ABclonal","offers":[{"title":"20ug","offer_id":45198385578163,"sku":"RP03266-20","price":308.0,"currency_code":"CAD","in_stock":true},{"title":"50ug","offer_id":45198385610931,"sku":"RP03266-50","price":490.0,"currency_code":"CAD","in_stock":true},{"title":"100ug","offer_id":45198385643699,"sku":"RP03266-100","price":784.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/download_aceb790c-c950-4e14-a988-a648571d9a5b.png?v=1766961539","url":"https:\/\/afsbio.com\/products\/recombinant-human-r-spondin-2-rspo2-protein-rp03266","provider":"AFSBio Inc.","version":"1.0","type":"link"}