{"product_id":"recombinant-human-rbp4-protein-his-tagactive-pksh031655","title":"Recombinant Human RBP4 Protein (His Tag)(Active) - PKSH031655","description":"Recombinant Human RBP4 Protein (His Tag)(Active)\n\nSize: 100μg\n\nCatalogue Number: PKSH031655-100\n\nCitations, Manuals and MSDS Available upon request.\n\nAbbreviation: RBP4\n\nTarget Symptom: RDCCAS; Retinol-Binding Protein 4; Plasma Retinol-Binding Protein; PRBP; RBP; RBP4\n\nResearch Area: Signal Transduction; Cardiovascular; Cancer; epigenetics and nuclear signal; metabolism; \n\nTarget Species: Human\n\nExpression Host: HEK293 Cells\n\nApplication: Enzyme\n\nFusion Tag: C-His\n\nAccession: NP_006735.2\n\nBackground: Retinol-binding protein 4 (RBP4) is the specific carrier for retinol (also known as vitamin A); and is responsible for the conversion of unstable and insoluble retinol in aqueous solution into stable and soluble complex in plasma through their tight interaction. As a member of the lipocalin superfamily; RBP4 containing a β -barrel structure with a well-defined cavity is secreted from the liver; and in turn delivers retinol from the liver stores to the peripheral tissues. In plasma; the RBP4-retinol complex interacts with transthyretin (TTR); and this binding is crucial for preventing RBP4 excretion through the kidney glomeruli. RBP4 expressed from an ectopic source efficiently delivers retinol to the eyes; and its deficiency affects night vision largely. Recently; RBP4 as an adipokine; is found to be expressed in adipose tissue and correlated with obesity; insulin resistance (IR) and type 2 diabetes (T2DM).\n\nActivity: Measured by its ability to bind all-trans retinoic acid. The binding of retinoic acid results in the quenching of Trp fluorescence in RBP4. The 50% binding concentration (BC50) is \u0026gt; 1.0 µM\n\nSequence: Met 1-Leu 201\n\nPurity: \u0026gt; 85 % as determined by reducing SDS-PAGE.\n\nFormulation: Lyophilized from sterile PBS, pH 7.2\nNormally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.\nPlease refer to the specific buffer information in the printed manual.\n\nReconstitution: Please refer to the printed manual for detailed information.\n\nEndotoxin: \u0026lt; 1.0 EU per μg of the protein as determined by the LAL method.\n\nObserved MW: 23 kDa\n\nStorage: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at \u0026lt; -20℃ for 3 months.\n\nShipping: This product is provided as lyophilized powder which is shipped with ice packs.\n\nResearch Use Only","brand":"Elabscience","offers":[{"title":"Default Title","offer_id":43107396976819,"sku":"PKSH031655-100","price":1024.8,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/products\/logo_new_a43a7891-b3d2-4baa-9979-c6a9b6b0ce91.png?v=1709383117","url":"https:\/\/afsbio.com\/products\/recombinant-human-rbp4-protein-his-tagactive-pksh031655","provider":"AFSBio Inc.","version":"1.0","type":"link"}