{"product_id":"recombinant-human-rida-hrsp12-protein-his-tag-pksh032526","title":"Recombinant Human RIDA\/HRSP12 Protein (His Tag) - PKSH032526","description":"\u003cp\u003eRecombinant Human RIDA\/HRSP12 Protein (His Tag)\u003c\/p\u003e\n\n\u003cp\u003eSizes: 10μg, 50μg\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: PKSH032526-10, PKSH032526-50\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eAbbreviation: RIDA; HRSP12\u003c\/p\u003e\n\n\u003cp\u003eTarget Synonym: Ribonuclease UK114; 14.5 kDa Translational Inhibitor Protein; p14.5; Heat-Responsive Protein 12; UK114 Antigen Homolog; HRSP12; PSP\u003c\/p\u003e\n\n\u003cp\u003eUNIProt ID: P52758\u003c\/p\u003e\n\n\u003cp\u003eResearch Areas: epigenetics and nuclear signal\u003c\/p\u003e\n\n\u003cp\u003eTarget Species: Human\u003c\/p\u003e\n\n\u003cp\u003eExpression Host: E.coli\u003c\/p\u003e\n\n\u003cp\u003eFusion Tag: N-6His\u003c\/p\u003e\n\n\u003cp\u003eAccession: P52758\u003c\/p\u003e\n\n\u003cp\u003eBackground: Heat-Responsive Protein 12 (HRSP12) is an endoribonuclease that belongs to the Rut family. HRSP12 is found mainly in the human adult kidney and liver and is responsible for inhibiting protein translation by cleaving mRNA. HRSP12 only cleaves phosphodiester bonds in single-stranded RNA and inhibits cell-free protein synthesis. The levels of both mRNA and protein are markedly reduced in heptatocellular tumors and in human hepatoma cell lines compared with normal liver tissues. Moreover the levels of HRSP12 are different depending on the grade of the tumor. This had led to the suggestion that HRSP12 may be an important biomarker for heptatic carcinoma.\u003c\/p\u003e\n\n\u003cp\u003eSequence: Met 1-Leu137\u003c\/p\u003e\n\n\u003cp\u003ePurity: \u0026gt; 95 % as determined by reducing SDS-PAGE.\u003c\/p\u003e\n\n\u003cp\u003eFormulation: Supplied as a 0.2 μm filtered solution of 20mM Tris-HCl, 100mM NaCl, 1mM DTT, 10% Glycerol, pH 8.0.\u003cbr\u003e\nNormally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.\u003cbr\u003e\nPlease refer to the specific buffer information in the printed manual.\u003c\/p\u003e\n\n\u003cp\u003eReconstitution: Not Applicable\u003c\/p\u003e\n\n\u003cp\u003eEndotoxin: \u0026lt; 1.0 EU per μg of the protein as determined by the LAL method.\u003c\/p\u003e\n\n\u003cp\u003eCalculated MW: 16.7 kDa\u003c\/p\u003e\n\n\u003cp\u003eObserved MW: 33 kDa\u003c\/p\u003e\n\n\u003cp\u003eStorage: Store at \u0026lt; -20°C, stable for 6 months. Please minimize freeze-thaw cycles.\u003c\/p\u003e\n\n\u003cp\u003eShipping: This product is provided as liquid. It is shipped at frozen temperature with blue ice\/gel packs. Upon receipt, store it immediately at \u0026lt; - 20°C.\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"Elabscience","offers":[{"title":"10μg","offer_id":43068844638387,"sku":"PKSH032526-10","price":343.0,"currency_code":"CAD","in_stock":true},{"title":"50μg","offer_id":43068844671155,"sku":"PKSH032526-50","price":574.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/products\/logo_new_f7c5a16c-1189-4250-a890-21bf19e7a059.png?v=1708598132","url":"https:\/\/afsbio.com\/products\/recombinant-human-rida-hrsp12-protein-his-tag-pksh032526","provider":"AFSBio Inc.","version":"1.0","type":"link"}