{"product_id":"recombinant-human-s100a8-s100a9-heterodimer-protein-his-tag-pksh033381","title":"Recombinant Human S100A8\u0026S100A9 Heterodimer Protein (His Tag) - PKSH033381","description":"\u003cp\u003eRecombinant Human S100A8\u0026amp;S100A9 Heterodimer Protein (His Tag)\u003c\/p\u003e\n\n\u003cp\u003eSizes: 10μg, 50μg\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: PKSH033381-10, PKSH033381-50\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eAbbreviation: S100A8\u0026amp;S100A9 Heterodimer\u003c\/p\u003e\n\n\u003cp\u003eTarget Symptom: S100A8\/S100A9 Heterodimer\u003c\/p\u003e\n\n\u003cp\u003eResearch Area: Signal Transduction; Cell biology; Neuroscience; Cancer; epigenetics and nuclear signal; immunology\u003c\/p\u003e\n\n\u003cp\u003eTarget Species: Human\u003c\/p\u003e\n\n\u003cp\u003eExpression Host: E.coli\u003c\/p\u003e\n\n\u003cp\u003eFusion Tag: C-6His\u003c\/p\u003e\n\n\u003cp\u003eUNIProt ID: P05109\u0026amp;P06702\u003c\/p\u003e\n\n\u003cp\u003eAccession: P05109\u0026amp;P06702\u003c\/p\u003e\n\n\u003cp\u003eBackground: S100A8 is a member of the S100 family, EF-hand superfamily of Ca-binding proteins. It is produced by neutrophils and monocytes, and forms Ca2+-dependent heterodimer\/heterotetramer complexes (termed calprotectin) with S100A9. Calprotectin (S100A8\/A9) which has a wide plethora of intra- and extracellular functions. The intracellular functions include: facilitating leukocyte arachidonic acid trafficking and metabolism, modulation of the tubulin-dependent cytoskeleton during migration of phagocytes and activation of the neutrophilic NADPH-oxidase.\u003c\/p\u003e\n\n\u003cp\u003eSequence: Met 1-Glu93(S100A8)\u0026amp;Thr 2-Pro114(S100A9)\u003c\/p\u003e\n\n\u003cp\u003ePurity: \u0026gt; 95 % as determined by reducing SDS-PAGE.\u003c\/p\u003e\n\n\u003cp\u003eFormulation: Supplied as a 0.2 μm filtered solution of 20mM HEPES, 10%Glycerol, 150mM NaCl, 2.5mM EDTA, pH 7.4.\u003cbr\u003e\nNormally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.\u003cbr\u003e\nPlease refer to the specific buffer information in the printed manual.\u003c\/p\u003e\n\n\u003cp\u003eReconstitution: Not Applicable\u003c\/p\u003e\n\n\u003cp\u003eEndotoxin: \u0026lt; 1.0 EU per μg of the protein as determined by the LAL method.\u003c\/p\u003e\n\n\u003cp\u003eCalculated MW: 11.7\u0026amp;13.2 kDa\u003c\/p\u003e\n\n\u003cp\u003eObserved MW: 15 kDa\u003c\/p\u003e\n\n\u003cp\u003eStorage: Store at \u0026lt; -20°C, stable for 6 months. Please minimize freeze-thaw cycles.\u003c\/p\u003e\n\n\u003cp\u003eShipping: This product is provided as liquid. It is shipped at frozen temperature with blue ice\/gel packs. Upon receipt, store it immediately at \u0026lt; - 20°C.\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"Elabscience","offers":[{"title":"10μg","offer_id":43113953853619,"sku":"PKSH033381-10","price":385.0,"currency_code":"CAD","in_stock":true},{"title":"50μg","offer_id":43113953886387,"sku":"PKSH033381-50","price":735.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/products\/logo_new_d224ef65-0d71-4832-86b2-cee2762e8730.png?v=1709549131","url":"https:\/\/afsbio.com\/products\/recombinant-human-s100a8-s100a9-heterodimer-protein-his-tag-pksh033381","provider":"AFSBio Inc.","version":"1.0","type":"link"}