{"product_id":"recombinant-human-senp7-protein-his-tag-pksh033027","title":"Recombinant Human SENP7 Protein (His Tag) - PKSH033027","description":"\u003cp\u003eRecombinant Human SENP7 Protein (His Tag)\u003c\/p\u003e\n\n\u003cp\u003eSizes: 10μg, 50μg\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: PKSH033027-10, PKSH033027-50\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eAbbreviation: SENP7\u003c\/p\u003e\n\n\u003cp\u003eTarget Synonym: Sentrin-Specific Protease 7; SUMO-1-Specific Protease 2; Sentrin\/SUMO-Specific Protease SENP7; SENP7; KIAA1707; SSP2; SUSP2\u003c\/p\u003e\n\n\u003cp\u003eUNIProt ID: Q9BQF6\u003c\/p\u003e\n\n\u003cp\u003eResearch Areas: Cell biology\u003c\/p\u003e\n\n\u003cp\u003eTarget Species: Human\u003c\/p\u003e\n\n\u003cp\u003eExpression Host: E.coli\u003c\/p\u003e\n\n\u003cp\u003eFusion Tag: N-6His\u003c\/p\u003e\n\n\u003cp\u003eAccession: Q9BQF6\u003c\/p\u003e\n\n\u003cp\u003eBackground: Sentrin-Specific Protease 7 (SENP7) acts as a SUMO-2\/3-specific protease. SENP7 is likely to regulate the metabolism of poly-SUMO-2\/3 rather than SUMO-1 conjugation in vivo. SENP7 has a restricted substrate specificity, and displaying paralogue-specific isopeptidase activity. The C-terminal catalytic domain of SENP7 depolymerized poly-SUMO-2 chains but does not have activity against poly-SUMO-1 chains. SENP7 also had isopeptidase activity against di-SUMO-2- and SUMO-2-modified RanGAP1 (Ran GTPase-activating protein 1) but had limited activity against SUMO-1-modified RanGAP1.\u003c\/p\u003e\n\n\u003cp\u003eSequence: Met695-Ala864\u003c\/p\u003e\n\n\u003cp\u003ePurity: \u0026gt; 95 % as determined by reducing SDS-PAGE.\u003c\/p\u003e\n\n\u003cp\u003eFormulation: Supplied as a 0.2 μm filtered solution of 20mM HEPES, 5% Glycerol, pH 7.4.\u003cbr\u003e\nNormally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.\u003cbr\u003e\nPlease refer to the specific buffer information in the printed manual.\u003c\/p\u003e\n\n\u003cp\u003eReconstitution: Not Applicable\u003c\/p\u003e\n\n\u003cp\u003eEndotoxin: \u0026lt; 1.0 EU per μg of the protein as determined by the LAL method.\u003c\/p\u003e\n\n\u003cp\u003eCalculated MW: 27.3 kDa\u003c\/p\u003e\n\n\u003cp\u003eObserved MW: 25 kDa\u003c\/p\u003e\n\n\u003cp\u003eStorage: Store at \u0026lt; -20°C, stable for 6 months. Please minimize freeze-thaw cycles.\u003c\/p\u003e\n\n\u003cp\u003eShipping: This product is provided as liquid. It is shipped at frozen temperature with blue ice\/gel packs. Upon receipt, store it immediately at \u0026lt; - 20°C.\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"Elabscience","offers":[{"title":"10μg","offer_id":43068801614003,"sku":"PKSH033027-10","price":385.0,"currency_code":"CAD","in_stock":true},{"title":"50μg","offer_id":43068801646771,"sku":"PKSH033027-50","price":735.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/products\/logo_new_dbc68eba-3596-44ab-8d01-36bd8b431671.png?v=1708597733","url":"https:\/\/afsbio.com\/products\/recombinant-human-senp7-protein-his-tag-pksh033027","provider":"AFSBio Inc.","version":"1.0","type":"link"}