{"product_id":"recombinant-human-serpin-c1-antithrombin-iii-protein-rp00140","title":"Recombinant Human Serpin C1\/Antithrombin-III Protein - RP00140","description":"\u003cp\u003eRecombinant Human Serpin C1\/Antithrombin-III Protein\u003c\/p\u003e\n\n\u003cp\u003eSizes: 20ug, 50ug, 100ug\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: RP00140-20, RP00140-50, RP00140-100\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eDescription: Recombinant Human SerpinC1\/AntithrombinIII\/ATIII Protein is produced by HEK293 expression system. The target protein is expressed with sequence (His33-Lys464) of human SerpinC1\/AntithrombinIII\/ATIII (Accession #NP_000479.1) fused with a 6×His tag at the C-terminus.\u003c\/p\u003e\n\n\u003cp\u003eAlternate Names: AT3, AT3D, ATIII, THPH7, SERPINC1, AT3D, ATIII, THPH7\u003c\/p\u003e\n\n\u003cp\u003eSWISS: P01008\u003c\/p\u003e\n\n\u003cp\u003eGeneID: 462\u003c\/p\u003e\n\n\u003cp\u003eSpecies: Human\u003c\/p\u003e\n\n\u003cp\u003ePurity: ≥ 95 % as determined by SDS-PAGE.\u003c\/p\u003e\n\n\u003cp\u003eStorage: Store at -20℃. Store the lyophilized protein at -20℃ to -80 ℃ up to 1 year from the date of receipt. After reconstitution, the protein solution is stable at -20℃ for 3 months, at 2-8℃ for up to 1 week.\u003c\/p\u003e\n\n\u003cp\u003eBackground: The protein is a plasma protease inhibitor and a member of the serpin superfamily. This protein inhibits thrombin as well as other activated serine proteases of the coagulation system, and it regulates the blood coagulation cascade. The protein includes two functional domains: the heparin binding-domain at the N-terminus of the mature protein, and the reactive site domain at the C-terminus. The inhibitory activity is enhanced by the presence of heparin. More than 120 mutations have been identified for this gene, many of which are known to cause antithrombin-III deficiency.\u003c\/p\u003e \n\n\u003cp\u003eBio-Activity: Measured by its ability to inhibit Recombinant Human Coagulation Factor II\/Thrombin cleavage of a fluorogenic peptide substrate Boc-VPR-AMC. The IC50 value is \u0026lt;0.48 nM.\u003c\/p\u003e\n\n\u003cp\u003eSource: HEK293 cells\u003c\/p\u003e\n\n\u003cp\u003eTag: C-His\u003c\/p\u003e\n\n\u003cp\u003eFormulation: Lyophilized from a 0.22 μm filtered solution of PBS, pH 7.4. Contact us for customized product form or formulation.\u003c\/p\u003e\n\n\u003cp\u003eAntigen Sequence: HGSPVDICTAKPRDIPMNPMCIYRSPEKKATEDEGSEQKIPEATNRRVWELSKANSRFATTFYQHLADSKNDNDNIFLSPLSISTAFAMTKLGACNDTLQQLMEVFKFDTISEKTSDQIHFFFAKLNCRLYRKANKSSKLVSANRLFGDKSLTFNETYQDISELVYGAKLQPLDFKENAEQSRAAINKWVSNKTEGRITDVIPSEAINELTVLVLVNTIYFKGLWKSKFSPENTRKELFYKADGESCSASMMYQEGKFRYRRVAEGTQVLELPFKGDDITMVLILPKPEKSLAKVEKELTPEVLQEWLDELEEMMLVVHMPRFRIEDGFSLKEQLQDMGLVDLFSPEKSKLPGIVAEGRDDLYVSDAFHKAFLEVNEEGSEAAASTAVVIAGRSLNPNRVTFKANRPFLVFIREVPLNTIIFMGRVANPCVK\u003c\/p\u003e\n\n\u003cp\u003eEndotoxin: \u0026lt; 0.1 EU\/μg of the protein by LAL method.\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"ABclonal","offers":[{"title":"20ug","offer_id":45198382694579,"sku":"RP00140-20","price":308.0,"currency_code":"CAD","in_stock":true},{"title":"50ug","offer_id":45198382727347,"sku":"RP00140-50","price":490.0,"currency_code":"CAD","in_stock":true},{"title":"100ug","offer_id":45198382760115,"sku":"RP00140-100","price":784.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/download_dfbb9185-b5df-4bca-9917-20ec092efd31.png?v=1766961501","url":"https:\/\/afsbio.com\/products\/recombinant-human-serpin-c1-antithrombin-iii-protein-rp00140","provider":"AFSBio Inc.","version":"1.0","type":"link"}