{"product_id":"recombinant-human-serpin-e1-pai-1-protein-rp00532","title":"Recombinant Human Serpin E1\/PAI-1 Protein - RP00532","description":"\u003cp\u003eRecombinant Human Serpin E1\/PAI-1 Protein\u003c\/p\u003e\n\n\u003cp\u003eSizes: 10ug, 20g, 50ug, 100ug\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: RP00532-10, RP00532-20, RP00532-50, RP00532-100\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eDescription: Recombinant Human Serpin E1\/PAI-1 Protein is produced by Human cells expression system. The target protein is expressed with sequence (Val24-Pro402) of human Serpin E1 (Accession #P05121) fused with a 6×His tag at the C-terminus.\u003c\/p\u003e\n\n\u003cp\u003eAlternate Names: PAI, PAI-1, PAI1, PLANH1, SERPINE1\u003c\/p\u003e\n\n\u003cp\u003eSWISS: P05121\u003c\/p\u003e\n\n\u003cp\u003eGeneID: 5054\u003c\/p\u003e\n\n\u003cp\u003eSpecies: Human\u003c\/p\u003e\n\n\u003cp\u003ePurity: ≥ 95 % as determined by SDS-PAGE.\u003c\/p\u003e\n\n\u003cp\u003eStorage: Store at -20 ℃. Store the lyophilized protein at -20℃ to -80 ℃ up to 1 year from the date of receipt. After reconstitution, the protein solution is stable at -20℃ for 3 months, at 2-8℃ for up to 1 week.\u003c\/p\u003e\n\n\u003cp\u003eBackground: Serpins are a group of proteins with similar structures that were first identified as a set of proteins able toinhibit proteases. They are the largest and most diverse family of serine protease inhibitors which are involvedin a number of fundamental biological processes such as blood coagulation, complement activation,fibrinolysis, angiogenesis, inflammation and tumor suppression and are expressed in a cell-specific manner.Serpin E1 is a secreted protein which belongs to the Serpin family. Serpin E1 acts as 'bait' for tissueplasminogen activator, urokinase, and protein C. Its rapid interaction with TPA may function as a major controlpoint in the regulation of fibrinolysis. Defects in SERPINE1 are characterized by abnormal bleeding due toSerpin E1 defect in the plasma. High concentrations of Serpin E1 have been associated with thrombophiliawhich is an autosomal dominant disorder in which affected individuals are prone to develop seriousspontaneous thrombosis.\u003c\/p\u003e\n\n\u003cp\u003eSource: HEK293 cells\u003c\/p\u003e\n\n\u003cp\u003eTag: C-His\u003c\/p\u003e\n\n\u003cp\u003eFormulation: Lyophilized from a 0.2 μm filtered solution of 20mM HAc-NaAc, 150mM NaCl, pH 4.0.Contact us for customized product form or formulation.\u003c\/p\u003e\n\n\u003cp\u003eAntigen Sequence: VHHPPSYVAHLASDFGVRVFQQVAQASKDRNVVFSPYGVASVLAMLQLTTGGETQQQIQAAMGFKIDDKGMAPALRHLYKELMGPWNKDEISTTDAIFVQRDLKLVQGFMPHFFRLFRSTVKQVDFSEVERARFIINDWVKTHTKGMISNLLGKGAVDQLTRLVLVNALYFNGQWKTPFPDSSTHRRLFHKSDGSTVSVPMMAQTNKFNYTEFTTPDGHYYDILELPYHGDTLSMFIAAPYEKEVPLSALTNILSAQLISHWKGNMTRLPRLLVLPKFSLETEVDLRKPLENLGMTDMFRQFQADFTSLSDQEPLHVAQALQKVKIEVNESGTVASSSTAVIVSARMAPEEIIMDRPFLFVVRHNPTGTVLFMGQVMEP\u003c\/p\u003e\n\n\u003cp\u003eEndotoxin: \u0026lt; 1 EU\/μg of the protein by LAL method.\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"ABclonal","offers":[{"title":"10ug","offer_id":45198237368499,"sku":"RP00532-10","price":210.0,"currency_code":"CAD","in_stock":true},{"title":"20ug","offer_id":45198237401267,"sku":"RP00532-20","price":308.0,"currency_code":"CAD","in_stock":true},{"title":"50ug","offer_id":45198237434035,"sku":"RP00532-50","price":490.0,"currency_code":"CAD","in_stock":true},{"title":"100ug","offer_id":45198237466803,"sku":"RP00532-100","price":784.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/download_2ad03af9-db7e-4b14-81b9-2e204a1b4f27.png?v=1766959577","url":"https:\/\/afsbio.com\/products\/recombinant-human-serpin-e1-pai-1-protein-rp00532","provider":"AFSBio Inc.","version":"1.0","type":"link"}