{"product_id":"recombinant-human-serpinb9-pi-9-protein-baculovirus-his-tag-pksh030777","title":"Recombinant Human SERPINB9\/PI-9 Protein (Baculovirus, His Tag) - PKSH030777","description":"\u003cp\u003eRecombinant Human SERPINB9\/PI-9 Protein (Baculovirus, His Tag)\u003c\/p\u003e\n\n\u003cp\u003eSize: 100μg\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: PKSH030777-100\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eAbbreviation: SERPINB9; PI-9\u003c\/p\u003e\n\n\u003cp\u003eTarget Synonym: Cytoplasmic antiproteinase 3; Peptidase inhibitor 9; CAP3; PI-9; Serpin B9\u003c\/p\u003e\n\n\u003cp\u003eUNIProt ID: P50453\u003c\/p\u003e\n\n\u003cp\u003eResearch Areas: Cell biology; immunology\u003c\/p\u003e\n\n\u003cp\u003eTarget Species: Human\u003c\/p\u003e\n\n\u003cp\u003eExpression Host: Baculovirus-Insect Cells\u003c\/p\u003e\n\n\u003cp\u003eFusion Tag: N-His\u003c\/p\u003e\n\n\u003cp\u003eAccession: P50453\u003c\/p\u003e\n\n\u003cp\u003eBackground: SerpinB9; also known as Cytoplasmic antiproteinase 3; CAP-3; Peptidase inhibitor 9; SERPINB9 and PI-9; is a cytoplasm protein which belongs to theserpin family and Ov-serpin subfamily. Serpin-B9 ( CAP-3 \/ PI-9 ) is the only known human intracellular inhibitor of granzyme B (GrB); the effector molecule in immunity against cytomegalovirus (CMV) and in renal allograft rejection. Serpin-B9 and SPI-6 expression in immune-privileged cells; APCs; and CTLs protects these cells against the actions of granzyme B; and when expressed in tumor cells or virally infected hepatocytes; confers resistance to killing by CTL and NK cells. Expression of increasing levels of Serpin-B9 ( CAP-3 \/ PI-9 ) in target cells may progressively inhibit immune surveillance by blocking NK and CTL-induced cytotoxicity through the perforin \/ granzyme pathway and then through the Fas \/ FasL pathway. Serpin-B9 ( CAP-3 \/ PI-9 ) is selectively up-regulated in hepatocytes in response to infiltration of the liver by NK cells that express perforin and enzymatically active granzyme B. Upregulated expression of Serpin-B9 ( CAP-3 \/ PI-9 ) in NSCLC cells may serve to protect them from apoptosis induced by GrB.\u003c\/p\u003e\n\n\u003cp\u003eSequence: Glu 2-Pro 376\u003c\/p\u003e\n\n\u003cp\u003ePurity: \u0026gt; 97 % as determined by reducing SDS-PAGE.\u003c\/p\u003e\n\n\u003cp\u003eFormulation: Lyophilized from sterile 50mM Tris, 100mM NaCl, pH 7.4\u003cbr\u003e\nNormally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.\u003cbr\u003e\nPlease refer to the specific buffer information in the printed manual.\u003c\/p\u003e\n\n\u003cp\u003eReconstitution: Please refer to the printed manual for detailed information.\u003c\/p\u003e\n\n\u003cp\u003eEndotoxin: \u0026lt; 1.0 EU per μg of the protein as determined by the LAL method.\u003c\/p\u003e\n\n\u003cp\u003eCalculated MW: 44.5 kDa\u003c\/p\u003e\n\n\u003cp\u003eObserved MW: 43 kDa\u003c\/p\u003e\n\n\u003cp\u003eStorage: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at \u0026lt; -20℃ for 3 months.\u003c\/p\u003e\n\n\u003cp\u003eShipping: This product is provided as lyophilized powder which is shipped with ice packs.\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"Elabscience","offers":[{"title":"100μg","offer_id":43083643060403,"sku":"PKSH030777-100","price":1024.8,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/products\/logo_new_4581ee00-93b5-4ca4-95f3-bf2cd7785c0a.png?v=1708945947","url":"https:\/\/afsbio.com\/products\/recombinant-human-serpinb9-pi-9-protein-baculovirus-his-tag-pksh030777","provider":"AFSBio Inc.","version":"1.0","type":"link"}