{"product_id":"recombinant-human-siglec-3-cd33-protein-rp00159","title":"Recombinant Human Siglec-3\/CD33 Protein - RP00159","description":"\u003cp\u003eRecombinant Human Siglec-3\/CD33 Protein\u003c\/p\u003e\n\n\u003cp\u003eSizes: 10ug, 20g, 50ug, 100ug\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: RP00159-10, RP00159-20, RP00159-50, RP00159-100\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eDescription: Recombinant Human Siglec-3\/CD33 Protein is produced by HEK293 expression system. The target protein is expressed with sequence (Asp18-His259) of human CD33\/Siglec-3 (Accession #NP_001763.3) fused with an Fc, 6×His tag at the C-terminus.\u003c\/p\u003e\n\n\u003cp\u003eAlternate Names: CD33, SIGLEC-3, SIGLEC3, p67, CD33 molecule, SIGLEC-3, SIGLEC3, p67\u003c\/p\u003e\n\n\u003cp\u003eSWISS: P20138\u003c\/p\u003e\n\n\u003cp\u003eGeneID: 945\u003c\/p\u003e\n\n\u003cp\u003eSpecies: Human\u003c\/p\u003e\n\n\u003cp\u003ePurity: ≥ 95 % as determined by SDS-PAGE.\u003c\/p\u003e\n\n\u003cp\u003eStorage: Store at -20 ℃. Store the lyophilized protein at -20℃ to -80 ℃ up to 1 year from the date of receipt. After reconstitution, the protein solution is stable at -20℃ for 3 months, at 2-8℃ for up to 1 week.\u003c\/p\u003e\n\n\u003cp\u003eBackground: Myeloid cell surface antigen CD33 also known as Sialic acid binding Ig-like lectin 3, CD33 antigen or Siglec-3, is a member of the immunoglobulin superfamily and SIGLEC (sialic acid binding Ig-like lectin) family. This Single-pass type I membrane protein contains 1 Ig-like C2-type (immunoglobulin-like) domain and 1 Ig-like V-type (immunoglobulin-like) domain. CD33\/Siglec-3 induces apoptosis in acute myeloid leukemia (in vitro). CD33\/Siglec-3 can function as a sialic acid-dependent cell adhesion molecule and that binding can be modulated by endogenous sialoglycoconjugates when CD33 is expressed in a plasma membrane.\u003c\/p\u003e\n\n\u003cp\u003eBio-Activity: Measured by its binding ability in a functional ELISA. Immobilized Human CD33 Protein at 1μg\/mL (100 μL\/well) can bind CD33 Rabbit pAb with a linear range of 0.03-1.66 ng\/mL.\u003c\/p\u003e\n\n\u003cp\u003eSource: HEK293 cells\u003c\/p\u003e\n\n\u003cp\u003eTag: C-hFc\u0026amp;His\u003c\/p\u003e\n\n\u003cp\u003eFormulation: Lyophilized from a 0.22 μm filtered solution of PBS, pH 7.4. Contact us for customized product form or formulation.\u003c\/p\u003e\n\n\u003cp\u003eAntigen Sequence: DPNFWLQVQESVTVQEGLCVLVPCTFFHPIPYYDKNSPVHGYWFREGAIISRDSPVATNKLDQEVQEETQGRFRLLGDPSRNNCSLSIVDARRRDNGSYFFRMERGSTKYSYKSPQLSVHVTDLTHRPKILIPGTLEPGHSKNLTCSVSWACEQGTPPIFSWLSAAPTSLGPRTTHSSVLIITPRPQDHGTNLTCQVKFAGAGVTTERTIQLNVTYVPQNPTTGIFPGDGSGKQETRAGVVH\u003c\/p\u003e\n\n\u003cp\u003eEndotoxin: \u0026lt; 0.1 EU\/μg of the protein by LAL method.\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"ABclonal","offers":[{"title":"10ug","offer_id":45198307819699,"sku":"RP00159-10","price":196.0,"currency_code":"CAD","in_stock":true},{"title":"20ug","offer_id":45198307852467,"sku":"RP00159-20","price":266.0,"currency_code":"CAD","in_stock":true},{"title":"50ug","offer_id":45198307885235,"sku":"RP00159-50","price":280.0,"currency_code":"CAD","in_stock":true},{"title":"100ug","offer_id":45198307918003,"sku":"RP00159-100","price":448.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/download_ea37284f-d63f-46a0-8edb-906c8c264940.png?v=1766960422","url":"https:\/\/afsbio.com\/products\/recombinant-human-siglec-3-cd33-protein-rp00159","provider":"AFSBio Inc.","version":"1.0","type":"link"}