{"product_id":"recombinant-human-signal-transducer-cd24-cd24-c-fc-pksh033968","title":"Recombinant Human Signal Transducer CD24\/CD24 (C-Fc) - PKSH033968","description":"\u003cp\u003eRecombinant Human Signal Transducer CD24\/CD24 (C-Fc)\u003c\/p\u003e\n\n\u003cp\u003eSizes: 10μg, 50μg\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: PKSH033968-10, PKSH033968-50\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eAbbreviation: CD24\u003c\/p\u003e\n\n\u003cp\u003eTarget Symptom: Signal transducer CD24; Small cell lung carcinoma cluster 4 antigen; CD24; CD24A\u003c\/p\u003e\n\n\u003cp\u003eResearch Area: Neuroscience; Cancer; immunology; metabolism; Stem cells\u003c\/p\u003e\n\n\u003cp\u003eTarget Species: Human\u003c\/p\u003e\n\n\u003cp\u003eExpression Host: HEK293 Cells\u003c\/p\u003e\n\n\u003cp\u003eApplication: ELISA\u003c\/p\u003e\n\n\u003cp\u003eFusion Tag: C-Fc\u003c\/p\u003e\n\n\u003cp\u003eUNIProt ID: P25063\u003c\/p\u003e\n\n\u003cp\u003eAccession: P25063\u003c\/p\u003e\n\n\u003cp\u003eBackground: Signal Transducer CD24 is a heavily and variably glycosylated GPI-linked sialoprotein. Human CD24 is expressed on B lineage cells and granulocytes, on epithelial, neuronal, and muscle cells, and on a range of tumor cells. CD24 expression is regulated during lineage development and with the activation of various cell types. Antibody crosslinking of CD24 enhances the induction of apoptosis in B and T lymphocytes which contributes to negative selection and the induction of immune tolerance. CD24 on antigen presenting cells cooperates with B7 molecules in the costimulation of T cells. CD24 associates in cis with Siglec10 and with the danger-associated molecules HMGB1, HSP70, or HSP90 which are released from necrotic or damaged cells. Formation of these ternary complexes fills a protective role: the resulting Siglec10 signaling inhibits inflammatory responses that are otherwise induced by extracellular DAMPs.\u003c\/p\u003e\n\n\u003cp\u003eActivity: Immobilized Anti-Human CD24 mAb at 2μg\/ml (100 μl\/well) can bind Human CD24-Fc: Biotinylated by NHS-biotin prior to testing. The ED50 of Human CD24-Fc is 7.62 ng\/ml.\u003c\/p\u003e\n\n\u003cp\u003eSequence: Ser27-Gly 59\u003c\/p\u003e\n\n\u003cp\u003ePurity: \u0026gt; 95 % as determined by reducing SDS-PAGE.\u003c\/p\u003e\n\n\u003cp\u003eFormulation: Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.\u003cbr\u003e\nNormally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.\u003cbr\u003e\nPlease refer to the specific buffer information in the printed manual.\u003c\/p\u003e\n\n\u003cp\u003eReconstitution: Please refer to the printed manual for detailed information.\u003c\/p\u003e\n\n\u003cp\u003eEndotoxin: \u0026lt; 1.0 EU per μg of the protein as determined by the LAL method.\u003c\/p\u003e\n\n\u003cp\u003eCalculated MW: 29.8 kDa\u003c\/p\u003e\n\n\u003cp\u003eObserved MW: 33-50 kDa\u003c\/p\u003e\n\n\u003cp\u003eStorage: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at \u0026lt; -20℃ for 3 months.\u003c\/p\u003e\n\n\u003cp\u003eShipping: This product is provided as lyophilized powder which is shipped with ice packs.\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"Elabscience","offers":[{"title":"10μg","offer_id":43118165688499,"sku":"PKSH033968-10","price":184.8,"currency_code":"CAD","in_stock":true},{"title":"50μg","offer_id":43118165721267,"sku":"PKSH033968-50","price":550.2,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/products\/logo_new_fd37a532-cff4-4e76-b9d6-09ca5d820f5d.png?v=1709637396","url":"https:\/\/afsbio.com\/products\/recombinant-human-signal-transducer-cd24-cd24-c-fc-pksh033968","provider":"AFSBio Inc.","version":"1.0","type":"link"}