{"product_id":"recombinant-human-slamf3-ly9-cd229-protein-rp02165","title":"Recombinant Human SLAMF3\/LY9\/CD229 Protein - RP02165","description":"\u003cp\u003eRecombinant Human SLAMF3\/LY9\/CD229 Protein\u003c\/p\u003e\n\n\u003cp\u003eSizes: 10ug, 50ug\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Number: RP02165-10, RP02165-50\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eDescription: Recombinant Human SLAMF3\/LY9\/CD229 Protein is produced by Mammalian expression system. The target protein is expressed with sequence (Lys48-Lys454) of human SLAMF3 (Accession #Q9HBG7) fused with a 6xHis tag at the C- terminus.\u003c\/p\u003e\n\n\u003cp\u003eAlternate Names: LY9, CD229, SLAMF3, hly9, mLY9\u003c\/p\u003e\n\n\u003cp\u003eSWISS: Q9HBG7\u003c\/p\u003e\n\n\u003cp\u003eGeneID: 4063\u003c\/p\u003e\n\n\u003cp\u003eSpecies: Human\u003c\/p\u003e\n\n\u003cp\u003ePurity: ≥ 95 % as determined by SDS-PAGE.\u003c\/p\u003e\n\n\u003cp\u003eStorage: Store at -20℃. Store the lyophilized protein at -20℃ to -80 ℃ up to 1 year from the date of receipt. After reconstitution, the protein solution is stable at -20℃ for 3 months, at 2-8℃ for up to 1 week.\u003c\/p\u003e\n\n\u003cp\u003eBackground: SLAMF3 (CD229) is a type I transmembrane glycoprotein in the SLAM subgroup of the CD2 family. Mature human SLAMF3 consists of a 407 amino acid (aa) extracellular domain (ECD) with two Ig-like V-set and two Ig-like truncated C2-set domains. The ECD of human SLAMF3 shares 57% - 59% aa sequence identity with mouse and rat SLAMF3. Within the first two Ig-like domains that are common to all SLAM proteins, human SLAMF3 shares 24% - 39% aa sequence identity with human 2B4, BLAME, CD2F-10, CD84, CRACC, NTB-A, and SLAM. It is expressed on T and B cells, thymocytes, and more weakly on NK cells. It may participate in adhesion reactions between T lymphocytes and accessory cells by homophilic interaction. Promotes T-cell differentiation into a helper T-cell Th17 phenotype leading to increased IL-17 secretion; the costimulatory activity requires SH2D1A. SLAMF3 may be involved in the maintenance of peripheral cell tolerance by serving as a negative regulator of the immune response. It also disable autoantibody responses and inhibit IFN-gamma secretion by CD4+ T-cells and negatively regulate the size of thymic innate CD8+ T-cells and the development of invariant natural killer T (iNKT) cells.\u003c\/p\u003e\n\n\u003cp\u003eSource: HEK293 cells\u003c\/p\u003e\n\n\u003cp\u003eTag: C-His\u003c\/p\u003e\n\n\u003cp\u003eFormulation: Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4. Contact us for customized product form or formulation.\u003c\/p\u003e\n\n\u003cp\u003eEndotoxin: \u0026lt; 1 EU\/μg of the protein by LAL method.\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"ABclonal","offers":[{"title":"10ug","offer_id":45198351958195,"sku":"RP02165-10","price":210.0,"currency_code":"CAD","in_stock":true},{"title":"50ug","offer_id":45198351990963,"sku":"RP02165-50","price":350.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/download_79910c52-c5d2-4a68-9dca-4defa315c255.png?v=1766960953","url":"https:\/\/afsbio.com\/products\/recombinant-human-slamf3-ly9-cd229-protein-rp02165","provider":"AFSBio Inc.","version":"1.0","type":"link"}