{"product_id":"recombinant-human-slamf5-cd84-protein-rp02164","title":"Recombinant Human SLAMF5\/CD84 Protein - RP02164","description":"\u003cp\u003eRecombinant Human SLAMF5\/CD84 Protein\u003c\/p\u003e\n\n\u003cp\u003eSizes: 10ug, 20ug, 100ug\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: RP02164-10, RP02164-20, RP02164-100\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eDescription: Recombinant Human SLAMF5\/CD84 Protein is produced by Mammalian expression system. The target protein is expressed with sequence (Lys22-Arg220) of human SLAMF5 (Accession #Q9UIB8) fused with a 6xHis tag at the C- terminus.\u003c\/p\u003e\n\n\u003cp\u003eAlternate Names: CD84, LY9B, SLAMF5, hCD84, mCD84, CD84 molecule, LY9B, SLAMF5, hCD84, mCD84\u003c\/p\u003e\n\n\u003cp\u003eSWISS: Q9UIB8\u003c\/p\u003e\n\n\u003cp\u003eGeneID: 8832\u003c\/p\u003e\n\n\u003cp\u003eSpecies: Human\u003c\/p\u003e\n\n\u003cp\u003ePurity: ≥ 95 % as determined by SDS-PAGE.\u003c\/p\u003e\n\n\u003cp\u003eStorage: Store at -20℃. Store the lyophilized protein at -20℃ to -80 ℃ up to 1 year from the date of receipt. After reconstitution, the protein solution is stable at -20℃ for 3 months, at 2-8℃ for up to 1 week.\u003c\/p\u003e\n\n\u003cp\u003eBackground: SLAM family member 5 (SLAMF5\/CD84) is a type I transmembrane protein in the SLAM subgroup of the CD2 family. SLAM family proteins regulate multiple aspects of immune system function. Mature human CD84 consists of a 204 amino acid (aa) extracellular domain (ECD) with two Iglike domains,a 21 aa transmembrane segment, and a 99 aa cytoplasmic domain with two immunoreceptor tyrosinebased switch motifs (ITSMs). CD84 exhibits homophilic binding which is mediated by the N-terminal Ig-like domain. Ligation induces tyrosine phosphorylation in the cytoplasmic ITSMs which then recruit the signaling adaptor molecules SAP (SLAM-associated protein) and EAT-2(EWS\/Fli1-activated transcript 2).CD84 signaling inhibits Fc epsilon RI-induced mast cell activation but enhances platelet activation. LPS-induced macrophage activation,T cell proliferation and IFN-γproduction, and the interactions between T cells and B cells that are required for germinal center formation.\u003c\/p\u003e\n\n\u003cp\u003eSource: HEK293 cells\u003c\/p\u003e\n\n\u003cp\u003eTag: C-His\u003c\/p\u003e\n\n\u003cp\u003eFormulation: Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4. Contact us for customized product form or formulation.\u003c\/p\u003e\n\n\u003cp\u003eAntigen Sequence: KDSEIFTVNGILGESVTFPVNIQEPRQVKIIAWTSKTSVAYVTPGDSETAPVVTVTHRNYYERIHALGPNYNLVISDLRMEDAGDYKADINTQADPYTTTKRYNLQIYRRLGKPKITQSLMASVNSTCNVTLTCSVEKEEKNVTYNWSPLGEEGNVLQIFQTPEDQELTYTCTAQNPVSNNSDSISARQLCADIAMGFR\u003c\/p\u003e\n\n\u003cp\u003eEndotoxin: \u0026lt; 1 EU\/μg of the protein by LAL method.\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"ABclonal","offers":[{"title":"10ug","offer_id":45198370930867,"sku":"RP02164-10","price":196.0,"currency_code":"CAD","in_stock":true},{"title":"20ug","offer_id":45198370963635,"sku":"RP02164-20","price":196.0,"currency_code":"CAD","in_stock":true},{"title":"100ug","offer_id":45198370996403,"sku":"RP02164-100","price":448.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/download_19bc3145-2f98-4645-b862-8181d584c83f.png?v=1766961326","url":"https:\/\/afsbio.com\/products\/recombinant-human-slamf5-cd84-protein-rp02164","provider":"AFSBio Inc.","version":"1.0","type":"link"}