{"product_id":"recombinant-human-slamf6-ntb-a-cd352-protein-rp01959","title":"Recombinant Human SLAMF6\/NTB-A\/CD352 Protein - RP01959","description":"\u003cp\u003eRecombinant Human SLAMF6\/NTB-A\/CD352 Protein\u003c\/p\u003e\n\n\u003cp\u003eSizes: 10ug, 20g, 50ug, 100ug\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: RP01959-10, RP01959-20, RP01959-50, RP01959-100\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eDescription: Recombinant Human SLAMF6\/NTB-A\/CD352 Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Gln22-Met226) of Human SLAMF6\/NTB-A\/CD352 (Accession #NP_001171643.1) fused with a hFc tag at the C-terminus.\u003c\/p\u003e\n\n\u003cp\u003eAlternate Names: SLAMF6, KALI, UNQ6123\/PRO20080, SLAM family member 6, Activating NK receptor, NK-T-B-antigen, NTB-A, CD352\u003c\/p\u003e\n\n\u003cp\u003eSWISS: Q96DU3-1\u003c\/p\u003e\n\n\u003cp\u003eGeneID: 114836\u003c\/p\u003e\n\n\u003cp\u003eSpecies: Human\u003c\/p\u003e\n\n\u003cp\u003ePurity: ≥ 95 % as determined by SDS-PAGE.\u003c\/p\u003e\n\n\u003cp\u003eStorage: Store at -20 ℃. Store the lyophilized protein at -20℃ to -80 ℃ up to 1 year from the date of receipt. After reconstitution, the protein solution is stable at -20℃ for 3 months, at 2-8℃ for up to 1 week.\u003c\/p\u003e\n\n\u003cp\u003eBackground: SLAM Family Member 6 (SLAMF6) is a 60 kD single-pass type I membrane protein that belongs to the SLAM subgroup of the CD2 family. Human SLAMF6\/ NTB-A contains a 205 amino acid extracellular domain (ECD) with one Ig-like V-set and one Ig-like C2-set domain, a 21 amino acid transmembrane segment and an 84 amino acid cytoplasmic domain, with two immunoreceptor tyrosine-based switch motifs. SLAMF6 is a homodimer. SLAMF6 can interact with PTN6 and, upon phosphorylation, with PTN11 and SH2D1A\/SAP. Phosphorylation-dependent NTB-A association with SAP is required for full production of IFN- γ by NK cells and independent of EAT-2 binding. It Triggers cytolytic activity only in natural killer cells (NK) expressing high surface densities of natural cytotoxicity receptors. On B cells, NTB-A modulates immunoglobulin class switching and the balance between tolerance and autoimmunity.\u003c\/p\u003e\n\n\u003cp\u003eSource: HEK293 cells\u003c\/p\u003e\n\n\u003cp\u003eTag: C-hFc\u003c\/p\u003e\n\n\u003cp\u003eFormulation: Lyophilized from a 0.22 μm filtered solution of PBS, pH 7.4.\u003c\/p\u003e\n\n\u003cp\u003eAntigen Sequence: QSSLTPLMVNGILGESVTLPLEFPAGEKVNFITWLFNETSLAFIVPHETKSPEIHVTNPKQGKRLNFTQSYSLQLSNLKMEDTGSYRAQISTKTSAKLSSYTLRILRQLRNIQVTNHSQLFQNMTCELHLTCSVEDADDNVSFRWEALGNTLSSQPNLTVSWDPRISSEQDYTCIAENAVSNLSFSVSAQKLCEDVKIQYTDTKM\u003c\/p\u003e\n\n\u003cp\u003eEndotoxin: \u0026lt; 0.01 EU\/μg of the protein by LAL method\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"ABclonal","offers":[{"title":"10ug","offer_id":45198256111795,"sku":"RP01959-10","price":196.0,"currency_code":"CAD","in_stock":true},{"title":"20ug","offer_id":45198256144563,"sku":"RP01959-20","price":266.0,"currency_code":"CAD","in_stock":true},{"title":"50ug","offer_id":45198256177331,"sku":"RP01959-50","price":280.0,"currency_code":"CAD","in_stock":true},{"title":"100ug","offer_id":45198256210099,"sku":"RP01959-100","price":448.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/download_733a8a56-c0f7-426f-a9ce-a58fbcffb763.png?v=1766959796","url":"https:\/\/afsbio.com\/products\/recombinant-human-slamf6-ntb-a-cd352-protein-rp01959","provider":"AFSBio Inc.","version":"1.0","type":"link"}