{"product_id":"recombinant-human-smad1-protein-gst-tag-pksh033065","title":"Recombinant Human SMAD1 Protein (GST Tag) - PKSH033065","description":"\u003cp\u003eRecombinant Human SMAD1 Protein (GST Tag)\u003c\/p\u003e\n\n\u003cp\u003eSizes: 10μg, 50μg\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: PKSH033065-10, PKSH033065-50\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eAbbreviation: SMAD1\u003c\/p\u003e\n\n\u003cp\u003eTarget Synonym: Mothers Against Decapentaplegic Homolog 1; MAD Homolog 1; Mothers Against DPP Homolog 1; JV4-1; Mad-Related Protein 1; SMAD Family Member 1; Transforming Growth Factor-Beta-Signaling Protein 1; BSP-1; SMAD1; BSP1; MADH1; SMAD 1; Smad1; hSMAD1; MADR1\u003c\/p\u003e\n\n\u003cp\u003eUNIProt ID: Q15797\u003c\/p\u003e\n\n\u003cp\u003eResearch Areas: Signal Transduction; Cancer; epigenetics and nuclear signal; metabolism; Stem cells\u003c\/p\u003e\n\n\u003cp\u003eTarget Species: Human\u003c\/p\u003e\n\n\u003cp\u003eExpression Host: E.coli\u003c\/p\u003e\n\n\u003cp\u003eFusion Tag: N-GST\u003c\/p\u003e\n\n\u003cp\u003eAccession: Q15797\u003c\/p\u003e\n\n\u003cp\u003eBackground: SMAD Family Member 1 (SMAD1) is a member of the dwarfin\/SMAD family. SMAD1 has the highest expression in the heart and skeletal muscle, containing one MAD homology 1 domain and one MAD homology 2 domain, As a transcriptional modulator SMAD 1 is activated by bone morphogenetic proteins type 1 receptor kinase. Defects in SMAD1 may cause primary pulmonary hypertension (PPH1), characterized by plexiform lesions of proliferating endothelial cells in pulmonary arterioles. The lesions lead to elevated pulmonary arterial pression, right ventricular failure and death.\u003c\/p\u003e\n\n\u003cp\u003eSequence: Met 1-Ser465\u003c\/p\u003e\n\n\u003cp\u003ePurity: \u0026gt; 95 % as determined by reducing SDS-PAGE.\u003c\/p\u003e\n\n\u003cp\u003eFormulation: Lyophilized from a 0.2 μm filtered solution of 20mM Tris-HCl, 150mM NaCl, pH 8.0 .\u003cbr\u003e\nNormally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.\u003cbr\u003e\nPlease refer to the specific buffer information in the printed manual.\u003c\/p\u003e\n\n\u003cp\u003eReconstitution: Please refer to the printed manual for detailed information.\u003c\/p\u003e\n\n\u003cp\u003eEndotoxin: \u0026lt; 1.0 EU per μg of the protein as determined by the LAL method.\u003c\/p\u003e\n\n\u003cp\u003eCalculated MW: 78.7 kDa\u003c\/p\u003e\n\n\u003cp\u003eObserved MW: 28\u0026amp;89 kDa\u003c\/p\u003e\n\n\u003cp\u003eStorage: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at \u0026lt; -20℃ for 3 months.\u003c\/p\u003e\n\n\u003cp\u003eShipping: This product is provided as lyophilized powder which is shipped with ice packs.\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"Elabscience","offers":[{"title":"10μg","offer_id":43068813902003,"sku":"PKSH033065-10","price":249.2,"currency_code":"CAD","in_stock":true},{"title":"50μg","offer_id":43068813934771,"sku":"PKSH033065-50","price":732.2,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/products\/logo_new_8c45471d-a9a9-4626-8e11-94b04cf998ae.png?v=1708597837","url":"https:\/\/afsbio.com\/products\/recombinant-human-smad1-protein-gst-tag-pksh033065","provider":"AFSBio Inc.","version":"1.0","type":"link"}