{"product_id":"recombinant-human-smpdl3a-protein-his-tag-pksh033291","title":"Recombinant Human SMPDL3A Protein (His Tag) - PKSH033291","description":"\u003cp\u003eRecombinant Human SMPDL3A Protein (His Tag)\u003c\/p\u003e\n\n\u003cp\u003eSizes: 10μg, 50μg\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: PKSH033291-10, PKSH033291-50\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eAbbreviation: SMPDL3A\u003c\/p\u003e\n\n\u003cp\u003eTarget Symptom: Acid Sphingomyelinase-Like Phosphodiesterase 3a; ASM-Like Phosphodiesterase 3a; SMPDL3A; ASML3A\u003c\/p\u003e\n\n\u003cp\u003eResearch Area: Signal Transduction; Cancer; metabolism;\u003c\/p\u003e \n\n\u003cp\u003eTarget Species: Human\u003c\/p\u003e\n\n\u003cp\u003eExpression Host: HEK293 Cells\u003c\/p\u003e\n\n\u003cp\u003eFusion Tag: C-6His\u003c\/p\u003e\n\n\u003cp\u003eUNIProt ID: Q92484\u003c\/p\u003e\n\n\u003cp\u003eAccession: Q92484\u003c\/p\u003e\n\n\u003cp\u003eBackground: Acid sphingomyelinase-like phosphodiesterase 3a (SMPDL3A ) is a novel liver X receptor (LXR) -regulated gene; with an LXR response element within its promoter. The induction of SMPDL3A is LXR-dependent and is restricted to human blood cells with no induction observed in mouse cellular systems. LXR function as physiological sensors of cholesterol metabolites (oxysterols); regulating key genes involved in cholesterol and lipid metabolism. LXRs have been extensively studied in both human and rodent cell systems; revealing their potential therapeutic value in the contexts of atherosclerosis and inflammatory diseases.\u003c\/p\u003e\n\n\u003cp\u003eSequence: Leu23-Tyr453\u003c\/p\u003e\n\n\u003cp\u003ePurity: \u0026gt; 95 % as determined by reducing SDS-PAGE.\u003c\/p\u003e\n\n\u003cp\u003eFormulation: Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.\u003cbr\u003e\nNormally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.\u003cbr\u003e\nPlease refer to the specific buffer information in the printed manual.\u003c\/p\u003e\n\n\u003cp\u003eReconstitution: Please refer to the printed manual for detailed information.\u003c\/p\u003e\n\n\u003cp\u003eEndotoxin: \u0026lt; 1.0 EU per μg of the protein as determined by the LAL method.\u003c\/p\u003e\n\n\u003cp\u003eCalculated MW: 49.9 kDa\u003c\/p\u003e\n\n\u003cp\u003eObserved MW: 59 kDa\u003c\/p\u003e\n\n\u003cp\u003eStorage: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at \u0026lt; -20℃ for 3 months.\u003c\/p\u003e\n\n\u003cp\u003eShipping: This product is provided as lyophilized powder which is shipped with ice packs.\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"Elabscience","offers":[{"title":"10μg","offer_id":43113943302323,"sku":"PKSH033291-10","price":249.2,"currency_code":"CAD","in_stock":true},{"title":"50μg","offer_id":43113943335091,"sku":"PKSH033291-50","price":732.2,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/products\/logo_new_5afeb511-7eb4-4f2e-8f90-e347c2461b2e.png?v=1709549009","url":"https:\/\/afsbio.com\/products\/recombinant-human-smpdl3a-protein-his-tag-pksh033291","provider":"AFSBio Inc.","version":"1.0","type":"link"}