{"product_id":"recombinant-human-snap25-protein-his-tag-pdeh100326","title":"Recombinant Human SNAP25 protein (His tag) - PDEH100326","description":"Recombinant Human SNAP25 protein (His tag)\n\nSize: 100μg\n\nCatalogue Numbers: PDEH100326-100\n\nCitations, Manuals and MSDS Available upon request.\n\nAbbreviation: SNAP25\n\nTarget Synonym: Synaptosomal-associated protein 25; SNAP25; SNAP-25; Super protein; Synaptosomal-associated 25 kDa protein\n\nUNIProt ID: P60880\n\nResearch Areas: Cancer; Metabolism; Neuroscience; Signal Transduction\n\nTarget Species: Human\n\nExpression Host: E.coli\n\nFusion Tag: N-His \u0026amp; C-His\n\nAccession: P60880-2\n\nBackground: Synaptosomal-associated protein 25, also known as Super protein, Synaptosomal-associated 25 kDa protein, SNAP25 and SNAP, is a cytoplasm and cell membrane protein which belongs to the  SNAP-25 family. SNAP25 \/ SUP contains 2  t-SNARE coiled-coil homology domains. SNAP25 \/ SUP is a membrane bound protein anchored to the cytosolic face of membranes via palmitoyl side chains in the middle of the molecule. SNAP25 \/ SUP protein is a component of the SNARE complex, which is proposed to account for the specificity of membrane fusion and to directly execute fusion by forming a tight complex that brings the synaptic vesicle and plasma membranes together. SNAP25 \/ SUP is a Q-SNARE protein contributing two α-helices in the formation of the exocytotic fusion complex in neurons where it assembles with syntaxin-1 and synaptobrevin. SNAP25 \/ SUP is involved in the molecular regulation of neurotransmitter release. It may play an important role in the synaptic function of specific neuronal systems. SNAP25 \/ SUP associates with proteins involved in vesicle docking and membrane fusion. SNAP25 \/ SUP regulates plasma membrane recycling through its interaction with CENPF. SNAP25 \/ SUP inhibits P\/Q- and L-type voltage-gated calcium channels located presynaptically and interacts with the synaptotagmin C2B domain in Ca2+-independent fashion. In glutamatergic synapses SNAP25 \/ SUP decreases the Ca2+ responsiveness, while it is naturally absent in GABAergic synapses.\n\nSequence: Met 1-Gly 206\n\nPurity: \u0026gt; 95 % as determined by reducing SDS-PAGE.\n\nFormulation: Lyophilized from sterile PBS, pH 7.4.\nNormally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.\nPlease refer to the specific buffer information in the printed manual.\n\nReconstitution: Please refer to the printed manual for detailed information.\n\nEndotoxin: Please contact us for more information.\n\nCalculated MW: 22.55 kDa\n\nObserved MW: 31 kDa\n\nStorage: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at \u0026lt; -20℃ for 3 months.\n\nShipping: This product is provided as lyophilized powder which is shipped with ice packs.\n\nResearch Use Only","brand":"Elabscience","offers":[{"title":"100μg","offer_id":43083546820787,"sku":"PDEH100326-100","price":165.2,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/products\/logo_new_9cea03ac-9137-4381-bea6-892f0521c40b.png?v=1708944468","url":"https:\/\/afsbio.com\/products\/recombinant-human-snap25-protein-his-tag-pdeh100326","provider":"AFSBio Inc.","version":"1.0","type":"link"}