{"product_id":"recombinant-human-socs3-cis3-protein-his-trx-tag-pksh031151","title":"Recombinant Human SOCS3\/CIS3 Protein (His \u0026 Trx Tag) - PKSH031151","description":"\u003cp\u003eRecombinant Human SOCS3\/CIS3 Protein (His \u0026amp; Trx Tag)\u003c\/p\u003e\n\n\u003cp\u003eSize: 50μg\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: PKSH031151-50\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eAbbreviation: SOCS3; CIS3\u003c\/p\u003e\n\n\u003cp\u003eTarget Synonym: ATOD4; CIS3; Cish3; SOCS-3; SSI-3; SSI3\u003c\/p\u003e\n\n\u003cp\u003eUNIProt ID: O14543\u003c\/p\u003e\n\n\u003cp\u003eResearch Areas: Signal Transduction; Cancer; epigenetics and nuclear signal; immunology; metabolism; Stem cells\u003c\/p\u003e\n\n\u003cp\u003eTarget Species: Human\u003c\/p\u003e\n\n\u003cp\u003eExpression Host: E.coli\u003c\/p\u003e\n\n\u003cp\u003eFusion Tag: N-Trx-His\u003c\/p\u003e\n\n\u003cp\u003eAccession: O14543\u003c\/p\u003e\n\n\u003cp\u003eBackground: Suppressor of cytokine signaling 3, also known as SOCS-3, Cytokine-inducible SH2 protein 3, CIS-3, STAT-induced STAT inhibitor 3, SOCS3 and CIS3, is a protein which is widely expressed with high expression in heart, placenta, skeletal muscle, peripheral blood leukocytes, fetal and adult lung, and fetal liver and kidney. SOCS3 \/ CIS3 contains oneSH2 domain and oneSOCS box domain. SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. SOCS3 \/ CIS3 is involved in negative regulation of cytokines that signal through the JAK \/ STAT pathway. SOCS3 \/ CIS3 inhibits cytokine signal transduction by binding to tyrosine kinase receptors including gp130, LIF, erythropoietin, insulin, IL12, GCSF and leptin receptors. Binding to JAK2 inhibits its kinase activity. SOCS3 \/ CIS3 suppresses fetal liver erythropoiesis. It regulates onset and maintenance of allergic responses mediated by T-helper type 2 cells. SOCS3 \/ CIS3 regulates IL-6 signaling. SOCS3 \/ CIS3 interacts with multiple activated proteins of the tyrosine kinase signaling pathway including IGF1 receptor, insulin receptor and JAK2. SOCS3 \/ CIS3 could be used as a possible therapeutic agent for treating rheumatoid arthritis.\u003c\/p\u003e\n\n\u003cp\u003eSequence: Met 1-Leu 225\u003c\/p\u003e\n\n\u003cp\u003ePurity: \u0026gt; 95 % as determined by reducing SDS-PAGE.\u003c\/p\u003e\n\n\u003cp\u003eFormulation: Lyophilized from sterile 50mM Tris, pH 8.0\u003cbr\u003e\nNormally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.\u003cbr\u003e\nPlease refer to the specific buffer information in the printed manual.\u003c\/p\u003e\n\n\u003cp\u003eReconstitution: Please refer to the printed manual for detailed information.\u003c\/p\u003e\n\n\u003cp\u003eEndotoxin: Please contact us for more information.\u003c\/p\u003e\n\n\u003cp\u003eCalculated MW: 41.9 kDa\u003c\/p\u003e\n\n\u003cp\u003eObserved MW: 46 kDa\u003c\/p\u003e\n\n\u003cp\u003eStorage: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at \u0026lt; -20℃ for 3 months.\u003c\/p\u003e\n\n\u003cp\u003eShipping: This product is provided as lyophilized powder which is shipped with ice packs.\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"Elabscience","offers":[{"title":"50μg","offer_id":43083646501043,"sku":"PKSH031151-50","price":1024.8,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/products\/logo_new_66ac758c-ae15-4a29-a95d-cbfbf8609f04.png?v=1708946083","url":"https:\/\/afsbio.com\/products\/recombinant-human-socs3-cis3-protein-his-trx-tag-pksh031151","provider":"AFSBio Inc.","version":"1.0","type":"link"}