{"product_id":"recombinant-human-sting-tmem173-protein-sumo-his-tag-pksh033517","title":"Recombinant Human STING\/TMEM173 Protein (Sumo \u0026 His Tag) - PKSH033517","description":"\u003cp\u003eRecombinant Human STING\/TMEM173 Protein (Sumo \u0026amp; His Tag)\u003c\/p\u003e\n\n\u003cp\u003eSizes: 10μg, 50μg\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: PKSH033517-10, PKSH033517-50\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eAbbreviation: STING; TMEM173\u003c\/p\u003e\n\n\u003cp\u003eTarget Symptom: Stimulator of interferon genes protein; TMEM173; Mediator of IRF3 activation; sting;\u003c\/p\u003e \n\n\u003cp\u003eResearch Area: Signal Transduction; Cancer; epigenetics and nuclear signal; immunology;\u003c\/p\u003e \n\n\u003cp\u003eTarget Species: Human\u003c\/p\u003e\n\n\u003cp\u003eExpression Host: E.coli\u003c\/p\u003e\n\n\u003cp\u003eFusion Tag: N-SUMO-His\u003c\/p\u003e\n\n\u003cp\u003eUNIProt ID: Q86WV6\u003c\/p\u003e\n\n\u003cp\u003eAccession: Q86WV6\u003c\/p\u003e\n\n\u003cp\u003eBackground: Stimulator of Interferon Gene(Sting, TMEM173) belongs to the TMEM173 family. STING is 379 amino acids (aa) in length. It contains an N-terminal cytoplasmic region (aa 1-20), four transmembrane segments (aa 21-173), and a C-terminal cytoplasmic domain (aa 174-379). It ubiquitously expressed in skin endothelial cells, alveolar type 2 pneumocytes, bronchial epithelium and alveolar macrophagesand. Its subunit structure associated with the MHC-II complex and Interacts with DDX58\/RIG-I, MAVS and SSR2, RNF5 and TRIM56 along with TBK1. This type of protein often uses as facilitator of innate immune signaling that acts as a sensor of cytosolic DNA from bacteria and viruses and promotes the production of type I interferon.\u003c\/p\u003e\n\n\u003cp\u003eSequence: Val155-Val341\u003c\/p\u003e\n\n\u003cp\u003ePurity: \u0026gt; 95 % as determined by reducing SDS-PAGE.\u003c\/p\u003e\n\n\u003cp\u003eFormulation: Supplied as a 0.2 μm filtered solution of PBS, pH7.4.\u003cbr\u003e\nNormally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.\u003cbr\u003e\nPlease refer to the specific buffer information in the printed manual.\u003c\/p\u003e\n\n\u003cp\u003eReconstitution: Not Applicable\u003c\/p\u003e\n\n\u003cp\u003eEndotoxin: \u0026lt; 1.0 EU per μg of the protein as determined by the LAL method.\u003c\/p\u003e\n\n\u003cp\u003eCalculated MW: 33.8 kDa\u003c\/p\u003e\n\n\u003cp\u003eObserved MW: 35 kDa\u003c\/p\u003e\n\n\u003cp\u003eStorage: Store at \u0026lt; -20°C, stable for 6 months. Please minimize freeze-thaw cycles.\u003c\/p\u003e\n\n\u003cp\u003eShipping: This product is provided as liquid. It is shipped at frozen temperature with blue ice\/gel packs. Upon receipt, store it immediately at \u0026lt; - 20°C.\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"Elabscience","offers":[{"title":"10μg","offer_id":43113964110003,"sku":"PKSH033517-10","price":385.0,"currency_code":"CAD","in_stock":true},{"title":"50μg","offer_id":43113964142771,"sku":"PKSH033517-50","price":735.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/products\/logo_new_88268fb4-3993-48e8-9ece-66d189309ae0.png?v=1709549280","url":"https:\/\/afsbio.com\/products\/recombinant-human-sting-tmem173-protein-sumo-his-tag-pksh033517","provider":"AFSBio Inc.","version":"1.0","type":"link"}