{"product_id":"recombinant-human-stk16-pkl12-mpsk-protein-his-nusa-tag-pksh030340","title":"Recombinant Human STK16\/PKL12\/MPSK Protein (His \u0026 NusA Tag) - PKSH030340","description":"\u003cp\u003eRecombinant Human STK16\/PKL12\/MPSK Protein (His \u0026amp; NusA Tag)\u003c\/p\u003e\n\n\u003cp\u003eSize: 50μg\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Number: PKSH030340-50\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eAbbreviation: STK16; PKL12; MPSK\u003c\/p\u003e\n\n\u003cp\u003eTarget Symptom: KRCT; MPSK; PKL12; TSF1\u003c\/p\u003e\n\n\u003cp\u003eTarget Species: Human\u003c\/p\u003e\n\n\u003cp\u003eExpression Host: E.coli\u003c\/p\u003e\n\n\u003cp\u003eFusion Tag: N-His \u0026amp; NusA\u003c\/p\u003e\n\n\u003cp\u003eAccession: AAH02618.1\u003c\/p\u003e\n\n\u003cp\u003eBackground: Serine\/threonine-protein kinase 16, also known as myristoylated and palmitoylated serine\/threonine-protein kinase, Protein kinase PKL12, TGF-beta-stimulated factor 1, TSF-1, MPSK1 and STK16, is a membrane protein which is ubiquitously expressed at very low levels. STK16 \/ MPSK1 belongs to theprotein kinase superfamily and Ser\/Thr protein kinase family. It contains oneprotein kinase domain. Transforming growth factor-beta (TGF-beta) shows a variety of biological activities in various organs or cells. Some factors such as Smads and TGF-beta activating kinase 1 have been characterized as signalling molecules downstream of TGF-beta. Several TGF-beta response elements have been identified such as cAMP response element, Smad binding element, and recognition sites for activating protein-1 and stimulating protein-1 in various gene promoters. STK16 \/ MPSK1 is an unique factor with two biological functions, transcriptional regulation and protein phosphorylation, that may be involved in TGF-beta signals. STK16 \/ MPSK1 is a protein kinase that act on both serine and threonine residues. STK16 \/ MPSK1 possessed DNA-binding ability and activated the TGF-beta responsive CNP promoter or vascular endothelial growth factor gene promoter which possesses a sequence element analogous to the TGF-beta responsive GC-rich element of the CNP promoter. STK16 \/ MPSK1 did not directly activate a Smads-dependent promoter from plasminogen activator inhibitor 1 gene, but it showed enhancement in co-operation with Smad3 and Smad4. STK16 \/ MPSK1 mRNA as well as its protein level were stimulated by TGF-beta treatment.\u003c\/p\u003e\n\n\u003cp\u003eSequence: Met 1-Ile 305\u003c\/p\u003e\n\n\u003cp\u003ePurity: \u0026gt; 85 % as determined by reducing SDS-PAGE.\u003c\/p\u003e\n\n\u003cp\u003eFormulation: Supplied as sterile solution of PBS, pH 7.4\u003cbr\u003e\nNormally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.\u003cbr\u003e\nPlease refer to the specific buffer information in the printed manual.\u003c\/p\u003e\n\n\u003cp\u003eReconstitution: Not Applicable\u003c\/p\u003e\n\n\u003cp\u003eEndotoxin: Please contact us for more information.\u003c\/p\u003e\n\n\u003cp\u003eCalculated MW: 92 kDa\u003c\/p\u003e\n\n\u003cp\u003eObserved MW: 105 kDa\u003c\/p\u003e\n\n\u003cp\u003eStorage: Store at \u0026lt; -20°C, stable for 6 months. Please minimize freeze-thaw cycles.\u003c\/p\u003e\n\n\u003cp\u003eShipping: This product is provided as liquid. It is shipped at frozen temperature with blue ice\/gel packs. Upon receipt, store it immediately at \u0026lt; - 20°C.\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"Elabscience","offers":[{"title":"Default Title","offer_id":43107397730483,"sku":"PKSH030340-50","price":796.6,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/products\/logo_new_953e5146-cc0c-480a-861a-a72891449271.png?v=1709383144","url":"https:\/\/afsbio.com\/products\/recombinant-human-stk16-pkl12-mpsk-protein-his-nusa-tag-pksh030340","provider":"AFSBio Inc.","version":"1.0","type":"link"}