{"product_id":"recombinant-human-thioredoxin-2-txn2-protein-his-tagactive-pksh030817","title":"Recombinant Human Thioredoxin-2\/TXN2 Protein (His Tag)(Active) - PKSH030817","description":"\u003cp\u003eRecombinant Human Thioredoxin-2\/TXN2 Protein (His Tag)(Active)\u003c\/p\u003e\n\n\u003cp\u003eSize: 100μg\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Number: PKSH030817-100\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eAbbreviation: Thioredoxin-2; TXN2\u003c\/p\u003e\n\n\u003cp\u003eTarget Symptom: Thioredoxin Mitochondrial; MTRX; Mt-Trx; Thioredoxin-2; TXN2; TRX2\u003c\/p\u003e\n\n\u003cp\u003eResearch Area: Signal Transduction; Cancer; metabolism;\u003c\/p\u003e \n\n\u003cp\u003eTarget Species: Human\u003c\/p\u003e\n\n\u003cp\u003eExpression Host: E.coli\u003c\/p\u003e\n\n\u003cp\u003eApplication: Enzyme\u003c\/p\u003e\n\n\u003cp\u003eFusion Tag: N-His\u003c\/p\u003e\n\n\u003cp\u003eUNIProt ID: Q99757\u003c\/p\u003e\n\n\u003cp\u003eAccession: Q99757\u003c\/p\u003e\n\n\u003cp\u003eBackground: Thioredoxin-2; also known as TXN2; MTRX and TRX2; is a member of the thioredoxin family. Tryparedoxins (TXN) are thioredoxin-related proteins which; as trypanothione:peroxiredoxin oxidoreductases; constitute the trypanothione-dependent antioxidant defense and may also serve as substrates for ribonucleotide reductase in trypanosomatids. Thioredoxin-2 \/ TXN2 contains onethioredoxin domain. It is widely expressed in adult (at protein level) and fetal tissues. Human Thioredoxin-2 \/ TXN2 is a small redox protein important in cellular antioxidant defenses; as well as in the regulation of apoptosis. Thioredoxin-2 \/ TXN2 has an anti-apoptotic function and plays an important role in the regulation of mitochondrial membrane potential. Thioredoxin-2 \/ TXN2 could be involved in the resistance to anti-tumor agents. It possesses a dithiol-reducing activity. Thioredoxin-2 \/ TXN2 plays an important role in protecting the mitochondria against oxidative stress and in sensitizing the cells to ROS-induced apoptosis. Mammalian Thioredoxin-2 \/ TXN2 is a mitochondrial isoform of highly evolutionary conserved thioredoxins. Thioredoxins are small ubiquitous protein-disulfide oxidoreductases implicated in a large variety of biological functions.\u003c\/p\u003e\n\n\u003cp\u003eActivity: Measured by its ability to catalyze the reduction of insulin. The reaction leads to precipitation, which can be measured by absorbance at 650 nm. The specific activity is 5-8 A650\/min\/mg.\u003c\/p\u003e\n\n\u003cp\u003eSequence: Thr 60-Gly 166\u003c\/p\u003e\n\n\u003cp\u003ePurity: \u0026gt; 97 % as determined by reducing SDS-PAGE.\u003c\/p\u003e\n\n\u003cp\u003eFormulation: Lyophilized from sterile PBS, pH 8.3\u003cbr\u003e\nNormally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.\u003cbr\u003e\nPlease refer to the specific buffer information in the printed manual.\u003c\/p\u003e\n\n\u003cp\u003eReconstitution: Please refer to the printed manual for detailed information.\u003c\/p\u003e\n\n\u003cp\u003eEndotoxin: Please contact us for more information.\u003c\/p\u003e\n\n\u003cp\u003eCalculated MW: 13.4 kDa\u003c\/p\u003e\n\n\u003cp\u003eObserved MW: 13 kDa\u003c\/p\u003e\n\n\u003cp\u003eStorage: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at \u0026lt; -20℃ for 3 months.\u003c\/p\u003e\n\n\u003cp\u003eShipping: This product is provided as lyophilized powder which is shipped with ice packs.\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"Elabscience","offers":[{"title":"Default Title","offer_id":43107257647283,"sku":"PKSH030817-100","price":1127.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/products\/logo_new_62f80a9a-4d4a-4ae2-936a-91f2d2b1a1c1.png?v=1709382053","url":"https:\/\/afsbio.com\/products\/recombinant-human-thioredoxin-2-txn2-protein-his-tagactive-pksh030817","provider":"AFSBio Inc.","version":"1.0","type":"link"}