{"product_id":"recombinant-human-tim-3-havcr2-cd366-protein-rp00069","title":"Recombinant Human TIM-3\/HAVCR2\/CD366 Protein - RP00069","description":"\u003cp\u003eRecombinant Human TIM-3\/HAVCR2\/CD366 Protein\u003c\/p\u003e\n\n\u003cp\u003eSizes: 10ug, 20g, 50ug, 100ug\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: RP00069-10, RP00069-20, RP00069-50, RP00069-100\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eDescription: Recombinant Human TIM-3\/HAVCR2\/CD366 Protein is produced by HEK293 expression system. The target protein is expressed with sequence (Ser22-Arg200) of human TIM-3 (Accession #NP_116171.3) fused with a 6×His tag at the C-terminus.\u003c\/p\u003e\n\n\u003cp\u003eAlternate Names: HAVCR2, CD366, HAVcr-2, KIM-3, TIM3, TIMD-3, TIMD3, Tim-3, CD366, KIM-3, SPTCL, TIMD3, Tim-3, TIMD-3, HAVcr-2\u003c\/p\u003e\n\n\u003cp\u003eSWISS: Q8TDQ0\u003c\/p\u003e\n\n\u003cp\u003eGeneID: 84868\u003c\/p\u003e\n\n\u003cp\u003eSpecies: Human\u003c\/p\u003e\n\n\u003cp\u003ePurity: ≥ 95 % as determined by SDS-PAGE.\u003c\/p\u003e\n\n\u003cp\u003eStorage: Store at -20 ℃. Store the lyophilized protein at -20℃ to -80 ℃ up to 1 year from the date of receipt. After reconstitution, the protein solution is stable at -20℃ for 3 months, at 2-8℃ for up to 1 week.\u003c\/p\u003e\n\n\u003cp\u003eBackground: The protein is belongs to the immunoglobulin superfamily, and TIM family of proteins. CD4-positive T helper lymphocytes can be divided into types 1 (Th1) and 2 (Th2) on the basis of their cytokine secretion patterns. Th1 cells are involved in cell-mediated immunity to intracellular pathogens and delayed-type hypersensitivity reactions, whereas, Th2 cells are involved in the control of extracellular helminthic infections and the promotion of atopic and allergic diseases. This protein is a Th1-specific cell surface protein that regulates macrophage activation, and inhibits Th1-mediated auto- and alloimmune responses, and promotes immunological tolerance.\u003c\/p\u003e \n\n\u003cp\u003eBio-Activity: Measured by its binding ability in a functional ELISA. Immobilized Recombinant Human Galectin9 at 2 μg\/mL can bind recombinant human HAVCR2 with a linear range of 0.3-5 μg\/mL.\u003c\/p\u003e\n\n\u003cp\u003eSource: HEK293 cells\u003c\/p\u003e\n\n\u003cp\u003eTag: C-His\u003c\/p\u003e\n\n\u003cp\u003eFormulation: Lyophilized from a 0.22 μm filtered solution of PBS, pH 7.4. Contact us for customized product form or formulation.\u003c\/p\u003e\n\n\u003cp\u003eAntigen Sequence: SEVEYRAEVGQNAYLPCFYTPAAPGNLVPVCWGKGACPVFECGNVVLRTDERDVNYWTSRYWLNGDFRKGDVSLTIENVTLADSGIYCCRIQIPGIMNDEKFNLKLVIKPAKVTPAPTRQRDFTAAFPRMLTTRGHGPAETQTLGSLPDINLTQISTLANELRDSRLANDLRDSGATIR\u003c\/p\u003e\n\n\u003cp\u003eEndotoxin: \u0026lt; 0.1 EU\/μg of the protein by LAL method.\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"ABclonal","offers":[{"title":"10ug","offer_id":45198293860531,"sku":"RP00069-10","price":182.0,"currency_code":"CAD","in_stock":true},{"title":"20ug","offer_id":45198293893299,"sku":"RP00069-20","price":252.0,"currency_code":"CAD","in_stock":true},{"title":"50ug","offer_id":45198293926067,"sku":"RP00069-50","price":280.0,"currency_code":"CAD","in_stock":true},{"title":"100ug","offer_id":45198293958835,"sku":"RP00069-100","price":420.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/download_061b9272-bd22-4b70-bf3f-f34aa04e4d5a.png?v=1766960232","url":"https:\/\/afsbio.com\/products\/recombinant-human-tim-3-havcr2-cd366-protein-rp00069","provider":"AFSBio Inc.","version":"1.0","type":"link"}