{"product_id":"recombinant-human-tnfrsf18-gitr-cd357-protein-rp01399","title":"Recombinant Human TNFRSF18\/GITR\/CD357 Protein - RP01399","description":"\u003cp\u003eRecombinant Human TNFRSF18\/GITR\/CD357 Protein\u003c\/p\u003e\n\n\u003cp\u003eSizes: 10ug, 20g, 50ug, 100ug\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: RP01399-10, RP01399-20, RP01399-50, RP01399-100\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eDescription: Recombinant Human TNFRSF18\/GITR\/CD357 Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Gln26-Glu161) of human GITR\/TNFRSF18 (Accession #NP_004186.1.) fused with a Fc, 6×His tag at the C-terminus.\u003c\/p\u003e\n\n\u003cp\u003eAlternate Names: TNFRSF18, AITR, CD357, GITR, GITR-D\u003c\/p\u003e\n\n\u003cp\u003eSWISS: Q9Y5U5-1\u003c\/p\u003e\n\n\u003cp\u003eGeneID: 8784\u003c\/p\u003e\n\n\u003cp\u003eSpecies: Human\u003c\/p\u003e\n\n\u003cp\u003ePurity: ≥ 95 % as determined by SDS-PAGE.\u003c\/p\u003e\n\n\u003cp\u003eStorage: Store at -20 ℃. Store the lyophilized protein at -20℃ to -80 ℃ up to 1 year from the date of receipt. After reconstitution, the protein solution is stable at -20℃ for 3 months, at 2-8℃ for up to 1 week.\u003c\/p\u003e\n\n\u003cp\u003eBackground: GITR, also known as TNFRSF18(CD357), belongs to the tumor necrosis factor receptor (TNF-R) superfamily. It is the receptor for TNFSF18. GITR plays a key role in dominant immunological self-tolerance maintained by CD25(+)CD4(+) regulatory T cells. GITR may be involved in interactions between activated T-lymphocytes and endothelial cells and in the regulation of T-cell receptor-mediated cell death. GITR and its ligand are important costimulatory molecules in the pathogenesis of autoimmune diseases. It also mediates NF-kappa-B activation via the TRAF2\/NIK pathway.\u003c\/p\u003e\n\n\u003cp\u003eBio-Activity: Measured by its binding ability in a functional ELISA.Immobilized Human TNFSF18 at 10 μg\/mL (100 μL\/well) can bind Human TNFRSF18 with a linear range of 0.8-14.5 μg\/mL.\u003c\/p\u003e\n\n\u003cp\u003eSource: HEK293 cells\u003c\/p\u003e\n\n\u003cp\u003eTag: C-hFc\u0026amp;His\u003c\/p\u003e\n\n\u003cp\u003eFormulation: Lyophilized from a 0.22 μm filtered solution of PBS, pH 7.4.\u003c\/p\u003e\n\n\u003cp\u003eAntigen Sequence: QRPTGGPGCGPGRLLLGTGTDARCCRVHTTRCCRDYPGEECCSEWDCMCVQPEFHCGDPCCTTCRHHPCPPGQGVQSQGKFSFGFQCIDCASGTFSGGHEGHCKPWTDCTQFGFLTVFPGNKTHNAVCVPGSPPAE\u003c\/p\u003e\n\n\u003cp\u003eEndotoxin: \u0026lt; 1 EU\/μg of the protein by LAL method.\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"ABclonal","offers":[{"title":"10ug","offer_id":45198318534835,"sku":"RP01399-10","price":182.0,"currency_code":"CAD","in_stock":true},{"title":"20ug","offer_id":45198318567603,"sku":"RP01399-20","price":252.0,"currency_code":"CAD","in_stock":true},{"title":"50ug","offer_id":45198318600371,"sku":"RP01399-50","price":280.0,"currency_code":"CAD","in_stock":true},{"title":"100ug","offer_id":45198318633139,"sku":"RP01399-100","price":420.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/download_90859bc0-6218-4ae1-b9d5-fe37ebc5eee9.png?v=1766960545","url":"https:\/\/afsbio.com\/products\/recombinant-human-tnfrsf18-gitr-cd357-protein-rp01399","provider":"AFSBio Inc.","version":"1.0","type":"link"}