{"product_id":"recombinant-human-tnfrsf4-ox40-cd134-protein-rp01357","title":"Recombinant Human TNFRSF4\/OX40\/CD134 Protein - RP01357","description":"\u003cp\u003eRecombinant Human TNFRSF4\/OX40\/CD134 Protein\u003c\/p\u003e\n\n\u003cp\u003eSizes: 10ug, 20g, 50ug, 100ug\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: RP01357-10, RP01357-20, RP01357-50, RP01357-100\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eDescription: Recombinant Human TNFRSF4\/OX40\/CD134 Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Leu29-Ala216) of human OX40\/TNFRSF4\/CD134 (Accession #NP_003318.1) fused with a 6×His tag at the C-terminus.\u003c\/p\u003e\n\n\u003cp\u003eAlternate Names: TNFRSF4, ACT35, CD134, IMD16, OX40, TXGP1L\u003c\/p\u003e\n\n\u003cp\u003eSWISS: P43489\u003c\/p\u003e\n\n\u003cp\u003eGeneID: 7293\u003c\/p\u003e\n\n\u003cp\u003eSpecies: Human\u003c\/p\u003e\n\n\u003cp\u003ePurity: ≥ 90 % as determined by SDS-PAGE.\u003c\/p\u003e\n\n\u003cp\u003eStorage: Store at -20 ℃. Store the lyophilized protein at -20℃ to -80 ℃ up to 1 year from the date of receipt. After reconstitution, the protein solution is stable at -20℃ for 3 months, at 2-8℃ for up to 1 week.\u003c\/p\u003e\n\n\u003cp\u003eBackground: OX40 (CD134) and its binding partner, OX40L (CD252), are members of the tumor necrosis factor receptor\/tumor necrosis factor superfamily, is known to break an existing state of tolerance in malignancies, leading to a reactivation of antitumor immunity. The interaction between OX40 and OX40L plays an important role in antigen-specific T-cell expansion and survival. OX40 and OX40L also regulate cytokine production from T cells, antigen-presenting cells, natural killer cells, and natural killer T cells, and modulate cytokine receptor signaling. In line with these important modulatory functions, OX40-OX40L interactions have been found to play a central role in the development of multiple inflammatory and autoimmune diseases, making them attractive candidates for intervention in the clinic. Conversely, stimulating OX40 has shown it to be a candidate for therapeutic immunization strategies for cancer and infectious disease.\u003c\/p\u003e\n\n\u003cp\u003eBio-Activity: Measured by its binding ability in a functional ELISA. Immobilized Human OX40 at 2 μg\/mL (100 μL\/well) can bind Human OX40 Ligand\/TNFSF4 Protein with a linear range of 156.25-872.87 ng\/mL.\u003c\/p\u003e\n\n\u003cp\u003eSource: HEK293 cells\u003c\/p\u003e\n\n\u003cp\u003eTag: C-His\u003c\/p\u003e\n\n\u003cp\u003eFormulation: Lyophilized from a 0.22 μm filtered solution of PBS, pH 7.4.\u003c\/p\u003e\n\n\u003cp\u003eAntigen Sequence: LHCVGDTYPSNDRCCHECRPGNGMVSRCSRSQNTVCRPCGPGFYNDVVSSKPCKPCTWCNLRSGSERKQLCTATQDTVCRCRAGTQPLDSYKPGVDCAPCPPGHFSPGDNQACKPWTNCTLAGKHTLQPASNSSDAICEDRDPPATQPQETQGPPARPITVQPTEAWPRTSQGPSTRPVEVPGGRAVA\u003c\/p\u003e\n\n\u003cp\u003eEndotoxin: Please contact us for more information.\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"ABclonal","offers":[{"title":"10ug","offer_id":45198345076915,"sku":"RP01357-10","price":196.0,"currency_code":"CAD","in_stock":true},{"title":"20ug","offer_id":45198345109683,"sku":"RP01357-20","price":266.0,"currency_code":"CAD","in_stock":true},{"title":"50ug","offer_id":45198345142451,"sku":"RP01357-50","price":280.0,"currency_code":"CAD","in_stock":true},{"title":"100ug","offer_id":45198345175219,"sku":"RP01357-100","price":448.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/download_e8351d22-7175-4921-8f3d-26b9eb670799.png?v=1766960852","url":"https:\/\/afsbio.com\/products\/recombinant-human-tnfrsf4-ox40-cd134-protein-rp01357","provider":"AFSBio Inc.","version":"1.0","type":"link"}