{"product_id":"recombinant-human-tnfrsf9-4-1bb-cd137-protein-rp01698","title":"Recombinant Human TNFRSF9\/4-1BB\/CD137 Protein - RP01698","description":"\u003cp\u003eRecombinant Human TNFRSF9\/4-1BB\/CD137 Protein\u003c\/p\u003e\n\n\u003cp\u003eSizes: 10ug, 20g, 50ug, 100ug\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: RP01698-10, RP01698-20, RP01698-50, RP01698-100\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eDescription: Recombinant Human Leukemia inhibitory factor\/LIF Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Leu24-Gln186) of human TNFRSF9\/4-1BB\/CD137 (Accession #NP_002300.1) fused with a 6×His tag at the C-terminus.\u003c\/p\u003e\n\n\u003cp\u003eAlternate Names: ILA; 4-1BB; CD137; CDw137; TNFRSF9\u003c\/p\u003e\n\n\u003cp\u003eSWISS: Q07011\u003c\/p\u003e\n\n\u003cp\u003eGeneID: 3604\u003c\/p\u003e\n\n\u003cp\u003eSpecies: Human\u003c\/p\u003e\n\n\u003cp\u003ePurity: ≥ 95 % as determined by SDS-PAGE.\u003c\/p\u003e\n\n\u003cp\u003eStorage: Store at -20 ℃. Store the lyophilized protein at -20℃ to -80 ℃ up to 1 year from the date of receipt. After reconstitution, the protein solution is stable at -20℃ for 3 months, at 2-8℃ for up to 1 week.\u003c\/p\u003e\n\n\u003cp\u003eBackground: CD137 (also known as 4-1BB) is a surface co-stimulatory glycoprotein originally described as present on activated T lymphocytes, which belongs to the tumor necrosis factor (TNF) receptor superfamily. It is expressed mainly on activated CD4+ and CD8+ T cells, and binds to a high-affinity ligand (4-1BBL) expressed on several antigen-presenting cells such as macrophages and activated B cells. Upon ligand binding, 4-1BB is associated with the tumor necrosis factor receptor–associated factors (TRAFs), the adaptor protein which mediates downstream signaling events including the activation of NF-kappaB and cytokine production. 4-1BB signaling either by binding to 4-1BBL or by antibody ligation delivers signals for T-cell activation and growth, as well as monocyte proliferation and B-cell survival, and plays an important role in the amplification of T cell-mediated immune responses.\u003c\/p\u003e\n\n\u003cp\u003eBio-Activity: Measured by its binding ability in a functional ELISA.Immobilized Human TNFRSF9 (Catalog: RP01698) at 2 μg\/mL (100 μL\/well) can bind Human TNFSF9 (Catalog: RP00060) with a linear range of 1-4.4 ng\/mL.\u003c\/p\u003e\n\n\u003cp\u003eSource: HEK293 cells\u003c\/p\u003e\n\n\u003cp\u003eTag: C-6His\u003c\/p\u003e\n\n\u003cp\u003eFormulation: Lyophilized from a 0.22 μm filtered solution of PBS, pH 7.4.\u003c\/p\u003e\n\n\u003cp\u003eAntigen Sequence: LQDPCSNCPAGTFCDNNRNQICSPCPPNSFSSAGGQRTCDICRQCKGVFRTRKECSSTSNAECDCTPGFHCLGAGCSMCEQDCKQGQELTKKGCKDCCFGTFNDQKRGICRPWTNCSLDGKSVLVNGTKERDVVCGPSPADLSPGASSVTPPAPAREPGHSPQ\u003c\/p\u003e\n\n\u003cp\u003eEndotoxin: \u0026lt; 0.1 EU\/μg of the protein by LAL method.\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"ABclonal","offers":[{"title":"10ug","offer_id":45198334853299,"sku":"RP01698-10","price":182.0,"currency_code":"CAD","in_stock":true},{"title":"20ug","offer_id":45198334886067,"sku":"RP01698-20","price":252.0,"currency_code":"CAD","in_stock":true},{"title":"50ug","offer_id":45198334918835,"sku":"RP01698-50","price":280.0,"currency_code":"CAD","in_stock":true},{"title":"100ug","offer_id":45198334951603,"sku":"RP01698-100","price":420.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/download_f2ab2b52-fa9d-4a61-97d2-d5db4f79b2bd.png?v=1766960722","url":"https:\/\/afsbio.com\/products\/recombinant-human-tnfrsf9-4-1bb-cd137-protein-rp01698","provider":"AFSBio Inc.","version":"1.0","type":"link"}