{"product_id":"recombinant-human-tnfsf12-tweak-protein-rp01446","title":"Recombinant Human TNFSF12\/TWEAK Protein - RP01446","description":"\u003cp\u003eRecombinant Human TNFSF12\/TWEAK Protein\u003c\/p\u003e\n\n\u003cp\u003eSizes: 10ug, 20g, 50ug, 100ug\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: RP01446-10, RP01446-20, RP01446-50, RP01446-100\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eDescription: Recombinant Human TNFSF12\/TWEAK Protein is produced by E. coli expression system. The target protein is expressed with sequence (Lys97-His249 (N-Met)) of human TWEAK\/TNFSF12 (Accession #NP_003800.1) fused with no additional amino acid.\u003c\/p\u003e\n\n\u003cp\u003eAlternate Names: TNFSF12, APO3L, DR3LG, TNLG4A, TWEAK\u003c\/p\u003e\n\n\u003cp\u003eSWISS: O43508-1\u003c\/p\u003e\n\n\u003cp\u003eGeneID: 8742\u003c\/p\u003e\n\n\u003cp\u003eSpecies: Human\u003c\/p\u003e\n\n\u003cp\u003ePurity: ≥ 95 % as determined by SDS-PAGE.\u003c\/p\u003e\n\n\u003cp\u003eStorage: Store at -20 ℃. Store the lyophilized protein at -20℃ to -80 ℃ up to 1 year from the date of receipt. After reconstitution, the protein solution is stable at -20℃ for 3 months, at 2-8℃ for up to 1 week.\u003c\/p\u003e\n\n\u003cp\u003eBackground: TNFSF12 is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. It is a ligand for the FN14\/TWEAKR receptor. TNFSF12 has overlapping signaling functions with TNF, but displays a much wider tissue distribution. It can induce apoptosis via multiple pathways of cell death in a cell type-specific manner. It is also found that TNFSF12 promotes proliferation and migration of endothelial cells, and thus acts as a regulator of angiogenesis. TNFSF12 also is a weak inducer of apoptosis in some cell types and mediates NF-kappa-B activation.\u003c\/p\u003e\n\n\u003cp\u003eBio-Activity: 1.Measured by its binding ability in a functional ELISA. Immobilized Human TNFSF12 at 2 μg\/mL (100 μL\/well) can bind Human TNFRSF12A with a linear range of 0.1-2.3 ng\/mL.|2.Measured in a cell proliferation assay using human umbilical vein endothelial cells (HUVEC). The ED50 for this effect is typically 0.81-3.24 ng\/mL.\u003c\/p\u003e\n\n\u003cp\u003eSource: E. coli\u003c\/p\u003e\n\n\u003cp\u003eTag: No tag\u003c\/p\u003e\n\n\u003cp\u003eFormulation: Lyophilized from a 0.22 μm filtered solution of PBS, pH 7.4.\u003c\/p\u003e\n\n\u003cp\u003eAntigen Sequence: KGRKTRARRAIAAHYEVHPRPGQDGAQAGVDGTVSGWEEARINSSSPLRYNRQIGEFIVTRAGLYYLYCQVHFDEGKAVYLKLDLLVDGVLALRCLEEFSATAASSLGPQLRLCQVSGLLALRPGSSLRIRTLPWAHLKAAPFLTYFGLFQVH\u003c\/p\u003e\n\n\u003cp\u003eEndotoxin: \u0026lt; 0.1 EU\/μg of the protein by LAL method.\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"ABclonal","offers":[{"title":"10ug","offer_id":45198329512115,"sku":"RP01446-10","price":210.0,"currency_code":"CAD","in_stock":true},{"title":"20ug","offer_id":45198329544883,"sku":"RP01446-20","price":280.0,"currency_code":"CAD","in_stock":true},{"title":"50ug","offer_id":45198329577651,"sku":"RP01446-50","price":350.0,"currency_code":"CAD","in_stock":true},{"title":"100ug","offer_id":45198329610419,"sku":"RP01446-100","price":560.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/download_67744237-644b-4126-8de0-8c0a3b30b9bc.png?v=1766960657","url":"https:\/\/afsbio.com\/products\/recombinant-human-tnfsf12-tweak-protein-rp01446","provider":"AFSBio Inc.","version":"1.0","type":"link"}