{"product_id":"recombinant-human-tnfsf14-light-protein-his-tag-pksh031639","title":"Recombinant Human TNFSF14\/LIGHT Protein (His Tag) - PKSH031639","description":"Recombinant Human TNFSF14\/LIGHT Protein (His Tag)\n\nSize: 100μg\n\nCatalogue Number: PKSH031639-100\n\nCitations, Manuals and MSDS Available upon request.\n\nAbbreviation: TNFSF14; LIGHT\n\nTarget Symptom: CD258; HVEML; LIGHT; LTg; TR2; Tumor necrosis factor ligand superfamily member 14; Herpes virus entry mediator ligand; TNFSF14; HVEM-L; LIGHT\n\nResearch Area: immunology\n\nTarget Species: Human\n\nExpression Host: HEK293 Cells\n\nFusion Tag: N-His\n\nAccession: NP_003798.2\n\nBackground: LIGHT, also known as TNFSF14 or CD258, is a newly identified member of the TNF superfamily (TNFSF14) that is expressed by activated T lymphocytes, monocytes, granulocytes, spleen cells, and immature dendritic cells. TNFSF14 \/ LIGHT \/ CD258 is a type II transmembrane protein that is known to bind 2 membrane-bound TNFSF signaling receptors: HVEM, which is predominantly expressed by T cells, and lymphotoxin β receptor (LTβ R), which is expressed by stromal cells and nonlymphoid hematopoietic cells. TNFSF14 \/ LIGHT \/ CD258 also binds to a soluble nonsignaling receptor, decoy receptor 3 (DcR3), which can modulate the function of LIGHT in vivo. TNFSF14 \/ LIGHT \/ CD258 can also costimulate T cell responses via HVEM, which is constitutively expressed in most lymphocyte subpopulations, including CD4+ and CD8+ T cells. In addition, TNFSF14 \/ LIGHT \/ CD258 has been shown to suppress tumor formation in vivo and to induce tumor cell apoptosis via the up-regulation of intercellular adhesion molecule 1 and an increased lymphocyte adhesion to cancer cells. Thus, TNFSF14 \/ LIGHT \/ CD258 is being actively investigated as a possible basis for cancer treatment.\n\nSequence: Asp 74-Val 240\n\nPurity: \u0026gt; 85 % as determined by reducing SDS-PAGE.\n\nFormulation: Lyophilized from sterile PBS, pH 7.4\nNormally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.\nPlease refer to the specific buffer information in the printed manual.\n\nReconstitution: Please refer to the printed manual for detailed information.\n\nEndotoxin: \u0026lt; 1.0 EU per μg of the protein as determined by the LAL method.\n\nCalculated MW: 20.4 kDa\n\nStorage: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at \u0026lt; -20℃ for 3 months.\n\nShipping: This product is provided as lyophilized powder which is shipped with ice packs.\n\nResearch Use Only","brand":"Elabscience","offers":[{"title":"Default Title","offer_id":43107365650611,"sku":"PKSH031639-100","price":945.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/products\/logo_new_00e5ecff-889b-43f8-8fbd-78812d3312d8.png?v=1709382811","url":"https:\/\/afsbio.com\/products\/recombinant-human-tnfsf14-light-protein-his-tag-pksh031639","provider":"AFSBio Inc.","version":"1.0","type":"link"}