{"product_id":"recombinant-human-tnfsf8-cd30-ligand-cd153-protein-rp01805","title":"Recombinant Human TNFSF8\/CD30 Ligand\/CD153 Protein - RP01805","description":"\u003cp\u003eRecombinant Human TNFSF8\/CD30 Ligand\/CD153 Protein\u003c\/p\u003e\n\n\u003cp\u003eSizes: 10ug, 20g, 50ug, 100ug\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: RP01805-10, RP01805-20, RP01805-50, RP01805-100\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eDescription: Recombinant Human TNFSF8\/CD30 Ligand\/CD153 Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Gln63-Asp234) of human TNFSF8\/CD30L (Accession #NP_001235.1) fused with 6×His tag at the N-t\u003c\/p\u003e\n\n\u003cp\u003eAlternate Names: CD153; CD30L; CD30LG; TNLG3A; TNFSF8\u003c\/p\u003e\n\n\u003cp\u003eSWISS: P32971\u003c\/p\u003e\n\n\u003cp\u003eGeneID: 944\u003c\/p\u003e\n\n\u003cp\u003eSpecies: Human\u003c\/p\u003e\n\n\u003cp\u003ePurity: ≥ 90 % as determined by SDS-PAGE.\u003c\/p\u003e\n\n\u003cp\u003eStorage: Store at -20 ℃. Store the lyophilized protein at -20℃ to -80 ℃ up to 1 year from the date of receipt. After reconstitution, the protein solution is stable at -20℃ for 3 months, at 2-8℃ for up to 1 week.\u003c\/p\u003e\n\n\u003cp\u003eBackground: CD30 ligand (CD30L), also known as CD153 and TNFSF8, is a membrane-associated glycoprotein belonging to the TNF superfamily and TNFR superfamily, and is a specific ligand for CD30\/TNFRSF8 originally described as a cell surface antigen and a marker for Hodgkin lymphoma and related hematologic malignancies. CD30L is a type-II membrane glycoprotein expressed on activated T cells, stimulated monocyte-macrophages, granulocytes, eosinophils, and some Burkitt-like lymphoma cell lines. CD30L is capable of transducing signals through CD30 on different CD30+ lymphoma cell lines, and mediates pleiotropic biologic effects including cell proliferation, activation, differentiation, as well as cell death by apoptosis. CD30-CD30 ligand interaction has been suggested to have a pathophysiologic role in malignant lymphomas, particularly Hodgkin disease, large cell anaplastic lymphomas and Burkitt lymphomas, and is also involved in activation and functioning of the T cell-dependent immune response. Thus, CD153 and its receptor CD30 are regarded as therapeutic targets in hematologic malignancies, autoimmune and inflammatory diseases.\u003c\/p\u003e\n\n\u003cp\u003eSource: HEK293 cells\u003c\/p\u003e\n\n\u003cp\u003eTag: N-His\u003c\/p\u003e\n\n\u003cp\u003eFormulation: Lyophilized from a 0.22 μm filtered solution of PBS, pH 7.4.\u003c\/p\u003e\n\n\u003cp\u003eAntigen Sequence: QRTDSIPNSPDNVPLKGGNCSEDLLCILKRAPFKKSWAYLQVAKHLNKTKLSWNKDGILHGVRYQDGNLVIQFPGLYFIICQLQFLVQCPNNSVDLKLELLINKHIKKQALVTVCESGMQTKHVYQNLSQFLLDYLQVNTTISVNVDTFQYIDTSTFPLENVLSIFLYSNSD\u003c\/p\u003e\n\n\u003cp\u003eEndotoxin: \u0026lt; 0.1 EU\/μg of the protein by LAL method.\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"ABclonal","offers":[{"title":"10ug","offer_id":45198265581747,"sku":"RP01805-10","price":196.0,"currency_code":"CAD","in_stock":true},{"title":"20ug","offer_id":45198265614515,"sku":"RP01805-20","price":266.0,"currency_code":"CAD","in_stock":true},{"title":"50ug","offer_id":45198265647283,"sku":"RP01805-50","price":280.0,"currency_code":"CAD","in_stock":true},{"title":"100ug","offer_id":45198265680051,"sku":"RP01805-100","price":448.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/download_a78b6698-3831-42b8-8341-228b5985c934.png?v=1766959897","url":"https:\/\/afsbio.com\/products\/recombinant-human-tnfsf8-cd30-ligand-cd153-protein-rp01805","provider":"AFSBio Inc.","version":"1.0","type":"link"}