{"product_id":"recombinant-human-tnfsf9-4-1bb-ligand-protein-rp00060","title":"Recombinant Human TNFSF9\/4-1BB Ligand Protein - RP00060","description":"\u003cp\u003eRecombinant Human TNFSF9\/4-1BB Ligand Protein\u003c\/p\u003e\n\n\u003cp\u003eSizes: 10ug, 20g, 50ug, 100ug\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: RP00060-10, RP00060-20, RP00060-50, RP00060-100\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eDescription: Recombinant Human TNFSF9\/4-1BB Ligand Protein is produced by E. coli expression system. The target protein is expressed with sequence (Arg71-Glu254) of human 4-1BB Ligand\/TNFSF9 (Accession #NP_003802.1) fused with a 6×His tag at the C-terminus.\u003c\/p\u003e\n\n\u003cp\u003eAlternate Names: 4-1BB-L, CD137L, TNLG5A, TNFSF9, CD137L, TNLG5A\u003c\/p\u003e\n\n\u003cp\u003eSWISS: P41273\u003c\/p\u003e\n\n\u003cp\u003eGeneID: 8744\u003c\/p\u003e\n\n\u003cp\u003eSpecies: Human\u003c\/p\u003e\n\n\u003cp\u003ePurity: ≥ 95 % as determined by SDS-PAGE.\u003c\/p\u003e\n\n\u003cp\u003eStorage: Store at -20 ℃. Store the lyophilized protein at -20℃ to -80 ℃ up to 1 year from the date of receipt. After reconstitution, the protein solution is stable at -20℃ for 3 months, at 2-8℃ for up to 1 week.\u003c\/p\u003e\n\n\u003cp\u003eBackground: The protein is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This transmembrane cytokine is a bidirectional signal transducer that acts as a ligand for TNFRSF9\/4-1BB, which is a costimulatory receptor molecule in T lymphocytes. This cytokine and its receptor are involved in the antigen presentation process and in the generation of cytotoxic T cells. The receptor TNFRSF9\/4-1BB is absent from resting T lymphocytes but rapidly expressed upon antigenic stimulation. The ligand encoded by this gene, TNFSF9\/4-1BBL, has been shown to reactivate anergic T lymphocytes in addition to promoting T lymphocyte proliferation. This cytokine has also been shown to be required for the optimal CD8 responses in CD8 T cells. This cytokine is expressed in carcinoma cell lines, and is thought to be involved in T cell-tumor cell interaction.\u003c\/p\u003e\n\n\u003cp\u003eBio-Activity: 1.Measured by its binding ability in a functional ELISA. Immobilized recombinant human TNFSF9 at 2 μg\/mL (100 μL\/well) can bind recombinant human TNFRSF9 with a linear range of 40-100 ng\/mL.|2.Measured by its binding ability in a functional ELISA. Immobilized Human TNFSF9\/4-1BB at 2 μg\/mL (100 μL\/well) can bind Human TNFRSF9\/4-1BB\/CD137 with a linear range of 0.1-5.8 ng\/mL.\u003c\/p\u003e\n\n\u003cp\u003eSource: E. coli\u003c\/p\u003e\n\n\u003cp\u003eTag: C-His\u003c\/p\u003e\n\n\u003cp\u003eFormulation: Lyophilized from a 0.22 μm filtered solution of 50mM Tris, 150mM NaCl, pH 8.0.Contact us for customized product form or formulation.\u003c\/p\u003e\n\n\u003cp\u003eAntigen Sequence: REGPELSPDDPAGLLDLRQGMFAQLVAQNVLLIDGPLSWYSDPGLAGVSLTGGLSYKEDTKELVVAKAGVYYVFFQLELRRVVAGEGSGSVSLALHLQPLRSAAGAAALALTVDLPPASSEARNSAFGFQGRLLHLSAGQRLGVHLHTEARARHAWQLTQGATVLGLFRVTPEIPAGLPSPRSE\u003c\/p\u003e\n\n\u003cp\u003eEndotoxin: \u0026lt; 0.1 EU\/μg of the protein by LAL method.\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"ABclonal","offers":[{"title":"10ug","offer_id":45198295466163,"sku":"RP00060-10","price":196.0,"currency_code":"CAD","in_stock":true},{"title":"20ug","offer_id":45198295498931,"sku":"RP00060-20","price":266.0,"currency_code":"CAD","in_stock":true},{"title":"50ug","offer_id":45198295531699,"sku":"RP00060-50","price":280.0,"currency_code":"CAD","in_stock":true},{"title":"100ug","offer_id":45198295564467,"sku":"RP00060-100","price":448.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/download_287be74a-b3cc-427d-a79b-23e7efc439cb.png?v=1766960255","url":"https:\/\/afsbio.com\/products\/recombinant-human-tnfsf9-4-1bb-ligand-protein-rp00060","provider":"AFSBio Inc.","version":"1.0","type":"link"}