{"product_id":"recombinant-human-tpbg-5t4-protein-his-tag-pksh033492","title":"Recombinant Human TPBG\/5T4 Protein (His Tag) - PKSH033492","description":"\u003cp\u003eRecombinant Human TPBG\/5T4 Protein (His Tag)\u003c\/p\u003e\n\n\u003cp\u003eSizes: 10μg, 50μg\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: PKSH033492-10, PKSH033492-50\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eAbbreviation: TPBG; 5T4\u003c\/p\u003e\n\n\u003cp\u003eTarget Symptom: 5T4 Protein; Human; 5T4AG Protein; Human; M6P1 Protein; Human; WAIF1 Protein; Human\u003c\/p\u003e\n\n\u003cp\u003eResearch Area: Cancer; Developmental Biology; immunology; Stem cells\u003c\/p\u003e\n\n\u003cp\u003eTarget Species: Human\u003c\/p\u003e\n\n\u003cp\u003eExpression Host: HEK293 Cells\u003c\/p\u003e\n\n\u003cp\u003eFusion Tag: C-His\u003c\/p\u003e\n\n\u003cp\u003eUNIProt ID: Q13641\u003c\/p\u003e\n\n\u003cp\u003eAccession: Q13641\u003c\/p\u003e\n\n\u003cp\u003eBackground: Trophoblast glycoprotein, also known as TPBG and 5T4, it belongs to the LRR family of proteins. The C-terminus of LRR N-terminal cap (LRRNT) and LRR 1 are essential for the inhibition of the Wnt signaling pathway. TPBG may function as an inhibitor of Wnt\/beta-catenin signaling by indirectly interacting with LRP6 and blocking Wnt3a-dependent LRP6 internalization. It expressed by all types of trophoblasts as early as 9 weeks of development. In adult tissues, the expression is limited to a few epithelial cell types but is found on a variety of carcinoma.\u003c\/p\u003e\n\n\u003cp\u003eSequence: Ser32-Ser355\u003c\/p\u003e\n\n\u003cp\u003ePurity: \u0026gt; 95 % as determined by reducing SDS-PAGE.\u003c\/p\u003e\n\n\u003cp\u003eFormulation: Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.\u003cbr\u003e\nNormally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.\u003cbr\u003e\nPlease refer to the specific buffer information in the printed manual.\u003c\/p\u003e\n\n\u003cp\u003eReconstitution: Please refer to the printed manual for detailed information.\u003c\/p\u003e\n\n\u003cp\u003eEndotoxin: \u0026lt; 1.0 EU per μg of the protein as determined by the LAL method.\u003c\/p\u003e\n\n\u003cp\u003eCalculated MW: 36.1 kDa\u003c\/p\u003e\n\n\u003cp\u003eObserved MW: 55-80 kDa\u003c\/p\u003e\n\n\u003cp\u003eStorage: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at \u0026lt; -20℃ for 3 months.\u003c\/p\u003e\n\n\u003cp\u003eShipping: This product is provided as lyophilized powder which is shipped with ice packs.\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"Elabscience","offers":[{"title":"10μg","offer_id":43113962176691,"sku":"PKSH033492-10","price":180.6,"currency_code":"CAD","in_stock":true},{"title":"50μg","offer_id":43113962209459,"sku":"PKSH033492-50","price":525.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/products\/logo_new_04551f69-0631-4be9-9c8c-7c6886b4e1a1.png?v=1709549234","url":"https:\/\/afsbio.com\/products\/recombinant-human-tpbg-5t4-protein-his-tag-pksh033492","provider":"AFSBio Inc.","version":"1.0","type":"link"}