{"product_id":"recombinant-human-trim5-rnf88-protein-his-tag-pksh033149","title":"Recombinant Human TRIM5\/RNF88 Protein (His Tag) - PKSH033149","description":"\u003cp\u003eRecombinant Human TRIM5\/RNF88 Protein (His Tag)\u003c\/p\u003e\n\n\u003cp\u003eSizes: 10μg, 50μg\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: PKSH033149-10, PKSH033149-50\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eAbbreviation: TRIM5; RNF88\u003c\/p\u003e\n\n\u003cp\u003eTarget Synonym: Tripartite motif-containing protein 5; RING finger protein 88; TRIM5; RNF88\u003c\/p\u003e\n\n\u003cp\u003eUNIProt ID: Q9C035\u003c\/p\u003e\n\n\u003cp\u003eResearch Areas: Cell biology; epigenetics and nuclear signal; immunology\u003c\/p\u003e\n\n\u003cp\u003eTarget Species: Human\u003c\/p\u003e\n\n\u003cp\u003eExpression Host: E.coli\u003c\/p\u003e\n\n\u003cp\u003eFusion Tag: N-6His\u003c\/p\u003e\n\n\u003cp\u003eAccession: Q9C035\u003c\/p\u003e\n\n\u003cp\u003eBackground: Tripartite motif-containing Motif 5 is a protein that in humans is encoded by the TRIM5 gene.It is a 493 amino acids protein that belongs to the TRIM\/RBCC family.It contains 1 B box-type zinc finger, 1 B30.2\/SPRY domain and 1 RING-type zinc finger. TRIM5 present in the cytoplasm recognizes motifs within the capsid proteins and interferes with the uncoating process, therefore preventing successful reverse transcription and transport to the nucleus of the viral genome. The exact mechanism of action has not been shown conclusively, but capsid protein from restricted viruses is removed by proteasome-dependent degradation\u003c\/p\u003e\n\n\u003cp\u003eSequence: Met 1-Gln248\u003c\/p\u003e\n\n\u003cp\u003ePurity: \u0026gt; 95 % as determined by reducing SDS-PAGE.\u003c\/p\u003e\n\n\u003cp\u003eFormulation: Supplied as a 0.2 μm filtered solution of 20mM PB, 150mM NaCl, pH7.4.\u003cbr\u003e\nNormally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.\u003cbr\u003e\nPlease refer to the specific buffer information in the printed manual.\u003c\/p\u003e\n\n\u003cp\u003eReconstitution: Not Applicable\u003c\/p\u003e\n\n\u003cp\u003eEndotoxin: \u0026lt; 1.0 EU per μg of the protein as determined by the LAL method.\u003c\/p\u003e\n\n\u003cp\u003eCalculated MW: 30.8 kDa\u003c\/p\u003e\n\n\u003cp\u003eObserved MW: 33 kDa\u003c\/p\u003e\n\n\u003cp\u003eStorage: Store at \u0026lt; -20°C, stable for 6 months. Please minimize freeze-thaw cycles.\u003c\/p\u003e\n\n\u003cp\u003eShipping: This product is provided as liquid. It is shipped at frozen temperature with blue ice\/gel packs. Upon receipt, store it immediately at \u0026lt; - 20°C.\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"Elabscience","offers":[{"title":"10μg","offer_id":43068834545843,"sku":"PKSH033149-10","price":312.2,"currency_code":"CAD","in_stock":true},{"title":"50μg","offer_id":43068834578611,"sku":"PKSH033149-50","price":830.2,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/products\/logo_new_09969aec-3243-460c-b7c8-5791fedb7ddd.png?v=1708598026","url":"https:\/\/afsbio.com\/products\/recombinant-human-trim5-rnf88-protein-his-tag-pksh033149","provider":"AFSBio Inc.","version":"1.0","type":"link"}