{"product_id":"recombinant-human-trk-a-ntrk1-protein-rp01726","title":"Recombinant human Trk-A\/NTRK1 Protein - RP01726","description":"\u003cp\u003eRecombinant human Trk-A\/NTRK1 Protein\u003c\/p\u003e\n\n\u003cp\u003eSizes: 10ug, 20g, 50ug, 100ug\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: RP01726-10, RP01726-20, RP01726-50, RP01726-100\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eDescription: Recombinant human Trk-A\/NTRK1 Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Ala33-Glu413) of human Trk-A\/NTRK1 (Accession #NP_001012331.1) fused with and a 6×His tag at the C-terminus.\u003c\/p\u003e\n\n\u003cp\u003eAlternate Names: MTC; TRK; TRK1; TRKA; Trk-A; p140-TrkA; NTRK1\u003c\/p\u003e\n\n\u003cp\u003eSWISS: P04629-1\u003c\/p\u003e\n\n\u003cp\u003eGeneID: 4914\u003c\/p\u003e\n\n\u003cp\u003eSpecies: human\u003c\/p\u003e\n\n\u003cp\u003ePurity: ≥ 90 % as determined by SDS-PAGE.\u003c\/p\u003e\n\n\u003cp\u003eStorage: Store at -20 ℃. Store the lyophilized protein at -20℃ to -80 ℃ up to 1 year from the date of receipt. After reconstitution, the protein solution is stable at -20℃ for 3 months, at 2-8℃ for up to 1 week.\u003c\/p\u003e\n\n\u003cp\u003eBackground: This protein is a member of the neurotrophic tyrosine kinase receptor (NTKR) family. This kinase is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. The presence of this kinase leads to cell differentiation and may play a role in specifying sensory neuron subtypes. Mutations in this gene have been associated with congenital insensitivity to pain, anhidrosis, self-mutilating behavior, mental retardation and cancer. Alternate transcriptional splice variants of this gene have been found, but only three have been characterized to date.\u003c\/p\u003e\n\n\u003cp\u003eBio-Activity: Measured by its ability to inhibit NGF-induced proliferation of TF‑1 human erythroleukemic cells. The ED50 for this effect is 0.086-0.34 µg\/mL in the presence of 10 ng\/mL of Recombinant Human beta-NGF.\u003c\/p\u003e\n\n\u003cp\u003eSource: HEK293 cells\u003c\/p\u003e\n\n\u003cp\u003eTag: C-6His\u003c\/p\u003e\n\n\u003cp\u003eFormulation: Lyophilized from a 0.22 μm filtered solution of PBS, pH 7.4.\u003c\/p\u003e\n\n\u003cp\u003eAntigen Sequence: AAPCPDACCPHGSSGLRCTRDGALDSLHHLPGAENLTELYIENQQHLQHLELRDLRGLGELRNLTIVKSGLRFVAPDAFHFTPRLSRLNLSFNALESLSWKTVQGLSLQELVLSGNPLHCSCALRWLQRWEEEGLGGVPEQKLQCHGQGPLAHMPNASCGVPTLKVQVPNASVDVGDDVLLRCQVEGRGLEQAGWILTELEQSATVMKSGGLPSLGLTLANVTSDLNRKNVTCWAENDVGRAEVSVQVNVSFPASVQLHTAVEMHHWCIPFSVDGQPAPSLRWLFNGSVLNETSFIFTEFLEPAANETVRHGCLRLNQPTHVNNGNYTLLAANPFGQASASIMAAFMDNPFEFNPEDPIPVSFSPVDTNSTSGDPVEKKDE\u003c\/p\u003e\n\n\u003cp\u003eEndotoxin: \u0026lt; 0.01 EU\/μg of the protein by LAL method\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"ABclonal","offers":[{"title":"10ug","offer_id":45198337147059,"sku":"RP01726-10","price":196.0,"currency_code":"CAD","in_stock":true},{"title":"20ug","offer_id":45198337179827,"sku":"RP01726-20","price":266.0,"currency_code":"CAD","in_stock":true},{"title":"50ug","offer_id":45198337212595,"sku":"RP01726-50","price":280.0,"currency_code":"CAD","in_stock":true},{"title":"100ug","offer_id":45198337245363,"sku":"RP01726-100","price":448.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/download_f20d2273-1ccc-414d-8cba-5847a7b3e1ff.png?v=1766960754","url":"https:\/\/afsbio.com\/products\/recombinant-human-trk-a-ntrk1-protein-rp01726","provider":"AFSBio Inc.","version":"1.0","type":"link"}