{"product_id":"recombinant-human-upar-plaur-cd87-protein-rp00295","title":"Recombinant Human uPAR\/PLAUR\/CD87 Protein - RP00295","description":"\u003cp\u003eRecombinant Human uPAR\/PLAUR\/CD87 Protein\u003c\/p\u003e\n\n\u003cp\u003eSizes: 10ug, 20g, 50ug, 100ug\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: RP00295-10, RP00295-20, RP00295-50, RP00295-100\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eDescription: Recombinant Human uPAR\/PLAUR\/CD87 Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Leu23-Arg303) of human uPAR (Accession #NP_002650.1) fused with a 6×His tag at the C-terminus.\u003c\/p\u003e\n\n\u003cp\u003eAlternate Names: PLAUR, CD87, U-PAR, UPAR, URKR, plasminogen activator, urokinase receptor, CD87, U-PAR, UPAR, URKR\u003c\/p\u003e\n\n\u003cp\u003eSWISS: Q03405\u003c\/p\u003e\n\n\u003cp\u003eGeneID: 5329\u003c\/p\u003e\n\n\u003cp\u003eSpecies: Human\u003c\/p\u003e\n\n\u003cp\u003ePurity: ≥ 95 % as determined by SDS-PAGE.\u003c\/p\u003e\n\n\u003cp\u003eStorage: Store at -20 ℃. Store the lyophilized protein at -20℃ to -80 ℃ up to 1 year from the date of receipt. After reconstitution, the protein solution is stable at -20℃ for 3 months, at 2-8℃ for up to 1 week.\u003c\/p\u003e\n\n\u003cp\u003eBackground: The secreted recombinant human UPAR consists of 292 amino acids with a molecular weight of 32.8 kDa. Recombinant human UPAR migrates as an about 48 kDa band in SDS-PAGE under reducing conditions due to glycosylation.Urokinase plasminogen activator surface receptor (U-PAR) is also known as PLAUR, Monocyte activation antigen Mo3, CD antigen CD87. U-PAR contains three UPAR\/Ly6 domains and is expressed in neurons of the rolandic area of the brain (at protein level). PLAUR \/ UPAR acts as a receptor for urokinase plasminogen activator and plays a role in localizing and promoting plasmin formation. Urokinase plasminogen activator (uPA) and\/or its receptor (uPAR) are essential for metastasis, and overexpression of these molecules is strongly correlated with poor prognosis in a variety of malignant tumours. Furthermore, the analysis of U-PAR expression has a potential role in the diagnostic or prognostic work-up of several hematological malignancies, particularly acute leukemia and multiple myeloma.\u003c\/p\u003e\n\n\u003cp\u003eBio-Activity: Measured by its binding ability in a functional ELISA.Immobilized Human PLAUR at 1 μg\/mL (100 μL\/well) can bind PLAUR Rabbit pAb with a linear range of 0.03-14.17ng\/mL.\u003c\/p\u003e\n\n\u003cp\u003eSource: HEK293 cells\u003c\/p\u003e\n\n\u003cp\u003eTag: C-His\u003c\/p\u003e\n\n\u003cp\u003eFormulation: Lyophilized from a 0.22 μm filtered solution of PBS, pH 7.4. Contact us for customized product form or formulation.\u003c\/p\u003e\n\n\u003cp\u003eAntigen Sequence: LRCMQCKTNGDCRVEECALGQDLCRTTIVRLWEEGEELELVEKSCTHSEKTNRTLSYRTGLKITSLTEVVCGLDLCNQGNSGRAVTYSRSRYLECISCGSSDMSCERGRHQSLQCRSPEEQCLDVVTHWIQEGEEGRPKDDRHLRGCGYLPGCPGSNGFHNNDTFHFLKCCNTTKCNEGPILELENLPQNGRQCYSCKGNSTHGCSSEETFLIDCRGPMNQCLVATGTHEPKNQSYMVRGCATASMCQHAHLGDAFSMNHIDVSCCTKSGCNHPDLDVQYR\u003c\/p\u003e\n\n\u003cp\u003eEndotoxin: \u0026lt; 0.1 EU\/μg of the protein by LAL method.\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"ABclonal","offers":[{"title":"10ug","offer_id":45198305460403,"sku":"RP00295-10","price":196.0,"currency_code":"CAD","in_stock":true},{"title":"20ug","offer_id":45198305493171,"sku":"RP00295-20","price":266.0,"currency_code":"CAD","in_stock":true},{"title":"50ug","offer_id":45198305525939,"sku":"RP00295-50","price":280.0,"currency_code":"CAD","in_stock":true},{"title":"100ug","offer_id":45198305558707,"sku":"RP00295-100","price":448.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/download_6580a13f-935e-4b6b-baa6-25c37e793f0b.png?v=1766960385","url":"https:\/\/afsbio.com\/products\/recombinant-human-upar-plaur-cd87-protein-rp00295","provider":"AFSBio Inc.","version":"1.0","type":"link"}