{"product_id":"recombinant-human-uteroglobin-scgb1a1-protein-his-tagactive-pksh031418","title":"Recombinant Human Uteroglobin\/SCGB1A1 Protein (His Tag)(Active) - PKSH031418","description":"Recombinant Human Uteroglobin\/SCGB1A1 Protein (His Tag)(Active)\n\nSize: 100μg\n\nCatalogue Number: PKSH031418-100\n\nCitations, Manuals and MSDS Available upon request.\n\nAbbreviation: Uteroglobin; SCGB1A1\n\nTarget Symptom: Uteroglobin; Clara cell phospholipid-binding protein; CCPBP; Clara cells 10 kDa secretory protein; CC10; Secretoglobin family 1A member 1; Urinary protein 1; UP-1; UP1; Urine protein 1; SCGB1A1; CCSP; UGB\n\nResearch Area: immunology\n\nTarget Species: Human\n\nExpression Host: HEK293 Cells\n\nApplication: Cell culture; ELISA\n\nFusion Tag: C-His\n\nUNIProt ID: P11684\n\nAccession: P11684\n\nBackground: Uteroglobin (UG); also known as Secretoglobin 1A member 1 (SCGB1A1); Blastokinin; Clara cell secretor protein (CCSP) or Clara cell-specific 10-kDa protein (CC10); is the founding member of the secretoglobin family of small; secreted; disulfide-bridged dimeric proteins found only in mammals. This protein is mainly expressed in lung; with anti-inflammatory\/immunomodulatory properties. Previous in vitro studies demonstrated that CCAAT\/enhancer-binding proteins (C\/EBPs) are the major transcription factors for the regulation of SCGB1A1 gene expression; whereas FOXA1 had a minimum effect on the transcription. Uteroglobin is a multifunctional protein with antiinflammatory\/immunomodulatory properties. Uteroglobin inhibits soluble phospholipase A(2) activity and binds and perhaps sequesters hydrophobic ligands such as progesterone; retinols; polychlorinated biphenyls; phospholipids; and prostaglandins. In addition to its antiinflammatory activities; Uteroglobin manifests antichemotactic; antiallergic; antitumorigenic; and embryonic growth-stimulatory activities. The tissue-specific expression of the Uteroglobin gene is regulated by several steroid hormones; although a nonsteroid hormone; prolactin; further augments its expression in the uterus. Based on its anti-inflammatory and antiallergic properties; Uteroglobin is a potential drug target. The mechanism of Uteroglobin action is likely to be even more complex as it also functions via a putative receptor-mediated pathway.\n\nActivity: Measured by the ability of the immobilized protein to support the adhesion of the A549 human lung carcinoma cell line. When 5 x 10\u003csup\u003e4\u003c\/sup\u003ecells\/well are added to human SCGB1A1 coated plates (2 μg\/ml and 100 μl\/well), approximately \u0026gt; 30% will adhere after one hour at 37 ℃.\n\nSequence: Met 1-Asn 91\n\nPurity: \u0026gt; 97 % as determined by reducing SDS-PAGE.\n\nFormulation: Lyophilized from sterile PBS, pH 7.4\nNormally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.\nPlease refer to the specific buffer information in the printed manual.\n\nReconstitution: Please refer to the printed manual for detailed information.\n\nEndotoxin: \u0026lt; 1.0 EU per μg of the protein as determined by the LAL method.\n\nCalculated MW: 9.2 kDa\n\nObserved MW: 9.2 kDa\n\nStorage: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at \u0026lt; -20℃ for 3 months.\n\nShipping: This product is provided as lyophilized powder which is shipped with ice packs.\n\nResearch Use Only","brand":"Elabscience","offers":[{"title":"Default Title","offer_id":43107261513907,"sku":"PKSH031418-100","price":789.6,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/products\/logo_new_b136b9a8-01dd-4428-a9b3-2a08ad9ed78f.png?v=1709382084","url":"https:\/\/afsbio.com\/products\/recombinant-human-uteroglobin-scgb1a1-protein-his-tagactive-pksh031418","provider":"AFSBio Inc.","version":"1.0","type":"link"}