{"product_id":"recombinant-human-xpnpep2-protein-his-tagactive-pksh030976","title":"Recombinant Human XPNPEP2 Protein (His Tag)(Active) - PKSH030976","description":"Recombinant Human XPNPEP2 Protein (His Tag)(Active)\n\nSize: 50μg\n\nCatalogue Number: PKSH030976-50\n\nCitations, Manuals and MSDS Available upon request.\n\nAbbreviation: XPNPEP2\n\nTarget Symptom: Xaa-Pro Aminopeptidase 2; Aminoacylproline Aminopeptidase; Membrane-Bound Aminopeptidase P; Membrane-Bound APP; Membrane-Bound AmP; mAmP; X-Pro Aminopeptidase 2; XPNPEP2\n\nResearch Area: Signal Transduction; Cell biology; Cancer; metabolism; \n\nTarget Species: Human\n\nExpression Host: HEK293 Cells\n\nApplication: Enzyme\n\nFusion Tag: C-His\n\nUNIProt ID: O43895\n\nAccession: O43895\n\nBackground: Aminopeptidase P (APP) is a hydrolase specific for N-terminal imido bonds; which are common to several collagen degradation products; neuropeptides; vasoactive peptides; and cytokines. A membrane-bound and soluble form of this enzyme (XPNPEP2) have been identified as products of two separate genes. XPNPEP2; the X-linked gene that encodes membranous aminopeptidase P (APP); has been reported to associate with APP activity. The membrane aminopeptidase P (XPNPEP2) is largely limited in distribution to endothelia and brush border epithelia. APP and XPNPEP2 contain homologous blocks of sequence common to members of the \" pita bread-fold\" protein family; of which Escherichia coli methionine aminopeptidase is the prototype. The C-2399A variant in XPNPEP2 is associated with reduced APP activity and a higher incidence of AE-ACEi. XPNPEP2 mRNA was detected in fibroblasts that carry the translocation; suggesting that this gene at least partially escapes X inactivation. XPNPEP2 is a candidate gene for premature ovarian failure (POF).\n\nActivity: Measured by its ability to cleave the fluorogenic peptide substrate, H-Lys(2-Aminobenzoyl)Pro-Pro-pNitroanilide(K(Abz)PP-pNA). The specific activity is \u0026gt; 300 pmoles\/min\/μg.\n\nSequence: Met 1-Ala 650\n\nPurity: \u0026gt; 97 % as determined by reducing SDS-PAGE.\n\nFormulation: Lyophilized from sterile PBS, pH 7.4\nNormally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.\nPlease refer to the specific buffer information in the printed manual.\n\nReconstitution: Please refer to the printed manual for detailed information.\n\nEndotoxin: \u0026lt; 1.0 EU per μg of the protein as determined by the LAL method.\n\nCalculated MW: 72 kDa\n\nStorage: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at \u0026lt; -20℃ for 3 months.\n\nShipping: This product is provided as lyophilized powder which is shipped with ice packs.\n\nResearch Use Only","brand":"Elabscience","offers":[{"title":"Default Title","offer_id":43107395207347,"sku":"PKSH030976-50","price":1213.8,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/products\/logo_new_99961a9a-43e2-41fe-910a-dacda0ffd4fd.png?v=1709383087","url":"https:\/\/afsbio.com\/products\/recombinant-human-xpnpep2-protein-his-tagactive-pksh030976","provider":"AFSBio Inc.","version":"1.0","type":"link"}