{"product_id":"recombinant-il-6r-human-bk0254","title":"Recombinant IL-6R, Human - BK0254","description":"\u003cp\u003eRecombinant IL-6R, Human\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: BK0254-10, BK0254-50\u003c\/p\u003e\n\n\u003cp\u003eSizes: 10μg, 50μg\u003c\/p\u003e\n\n\u003cp\u003eSource: CHO\u003c\/p\u003e\n\n\u003cp\u003eMolecular Weight: 54-56 kDa, observed by reducing SDS-PAGE.\u003c\/p\u003e\n\n\u003cp\u003ePurity: \u0026gt; 95% as analyzed by SDS-PAGE and HPLC.\u003c\/p\u003e\n\n\u003cp\u003eBiological Activity: ED50 \u0026lt; 0.2 μg\/ml, measured in a cell proliferation assay using M1 cells in the presence of 10 ng\/ml human IL-6.\u003c\/p\u003e\n\n\u003cp\u003ePhysical Appearance: Sterile Filtered White lyophilized (freeze-dried) powder.\u003c\/p\u003e\n\n\u003cp\u003eFormulation: Lyophilized after extensive dialysis against PBS.\u003c\/p\u003e\n\n\u003cp\u003eAA Sequence: LAPRRCPAQEVARGVLTSLPGDSVTLTCPGVEPEDNAt VHWVLRKPAAGSHPSRWAGMGRRLLLRSVQLHDSGNYSCYRA\u003cbr\u003e\n GRPAGt VHLLVDVPPEEPQLSCFRKSPLSNVVCEWGPRSTPSLTTKAVLLVRKFQNSPAEDFQEPCQYSQESQKFSCQLA\u003cbr\u003e\n VPEGDSSFYIVSMCVASSVGSKFSKTQTFQGCGILQPDPPANIt VTAVARNPRWLSVTWQDPHSWNSSFYRLRFELRYRA\u003cbr\u003e\n ERSKTFTTWMVKDLQHHCVIHDAWSGLRHVVQLRAQEEFGQGEWSEWSPEAMGTPWTESRSPPAENEVSTPMQALTTNKD\u003cbr\u003e\n DDNILFRDSANATSLPVQDSSSVPLP\u003c\/p\u003e\n\n\u003cp\u003eEndotoxin: \u0026lt; 0.2 EU\/μg, determined by LAL method.\u003c\/p\u003e\n\n\u003cp\u003eReconstitution: Reconstituted in ddH2O or PBS at 100 μg\/ml.\u003c\/p\u003e\n\n\u003cp\u003eStorage: Lyophilized recombinant Human Interleukin-6 Receptor Alpha remains stable up to 6 months at -80°C from date of receipt. Upon reconstitution, Human Interleukin-6 Receptor Alpha should be stable up to 1 week at 4°C or up to 2 months at -20°C.\u003c\/p\u003e\n\n\u003cp\u003eUsage: This material is offered by USA Bioworld biotech for research, laboratory or further evaluation purposes. For research use only.\u003c\/p\u003e\n\n\u003cp\u003eDescription: Interleukin-6 Receptor Alpha, also known as IL-6RA, IL-6R1 and CD126, belongs to the type I cytokine receptor family. It is mainly expressed on T cells, fibroblasts and macrophages. IL-6RA couples with gp130 to form the IL-6 receptor; IL-6RA binds specifically to IL-6 and depends on gp130 to transmit signals. IL-6RA dysfunction has been correlated with the pathogenesis of many diseases, such as multiple myeloma, autoimmune diseases and prostate cancer. Soluble IL-6RA, which consists of only the extracellular domain of IL-6RA, acts as an agonist of IL-6 activity.\u003c\/p\u003e","brand":"BioWorld","offers":[{"title":"10μg","offer_id":42882257027251,"sku":"BK0254-10","price":375.54,"currency_code":"CAD","in_stock":true},{"title":"50μg","offer_id":42882257060019,"sku":"BK0254-50","price":1152.94,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/products\/thumbnail_d1447bac803ec9be_11-14-09-19-51_9f96987d-013c-444b-aa27-0127223b17dc.jpg?v=1702050165","url":"https:\/\/afsbio.com\/products\/recombinant-il-6r-human-bk0254","provider":"AFSBio Inc.","version":"1.0","type":"link"}