{"product_id":"recombinant-macaca-nemestrina-pcsk9-proprotein-convertase-9-protein-his-tag-pksq050064","title":"Recombinant Macaca nemestrina PCSK9\/Proprotein Convertase 9 Protein (His Tag) - PKSQ050064","description":"\u003cp\u003eRecombinant Macaca nemestrina PCSK9\/Proprotein Convertase 9 Protein (His Tag)\u003c\/p\u003e\n\n\u003cp\u003eSizes: 10μg, 50μg\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: PKSQ050064-10, PKSQ050064-50\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eAbbreviation: PCSK9; Proprotein Convertase 9\u003c\/p\u003e\n\n\u003cp\u003eTarget Synonym: Proprotein Convertase Subtilisin\/Kexin Type 9; Proprotein Convertase 9; PC9; Subtilisin\/Kexin-Like Protease PC9; PCSK9\u003c\/p\u003e\n\n\u003cp\u003eUNIProt ID: A8T662\u003c\/p\u003e\n\n\u003cp\u003eTarget Species: Macaca nemestrina\u003c\/p\u003e\n\n\u003cp\u003eExpression Host: HEK293 Cells\u003c\/p\u003e\n\n\u003cp\u003eFusion Tag: C-His\u003c\/p\u003e\n\n\u003cp\u003eAccession: A8T662\u003c\/p\u003e\n\n\u003cp\u003eBackground: Proprotein Convertase Subtilisin\/Kexin Type 9 (PCSK9) is a secretory subtilase belonging to the proteinase K subfamily. PCSK9 is synthesized as a soluble zymogen that undergoes autocatalytic intramolecular processing in the ER, the pro domain and mature chain secrete together through noncovalent interactions. PCSK9 binds with low-density lipoprotein receptor (LDLR) and plays a major regulatory role in cholesterol homeostasis. PCSK9 also plays a role in the neural development.\u003c\/p\u003e\n\n\u003cp\u003eSequence: Gln31-Gln152\u0026amp;Ser153-Gln692\u003c\/p\u003e\n\n\u003cp\u003ePurity: \u0026gt; 95 % as determined by reducing SDS-PAGE.\u003c\/p\u003e\n\n\u003cp\u003eFormulation: Supplied as a 0.2 μm filtered solution of 50mM HEPES, 150mM NaCl, 20%Glycerol, pH 7.4.\u003cbr\u003e\nNormally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.\u003cbr\u003e\nPlease refer to the specific buffer information in the printed manual.\u003c\/p\u003e\n\n\u003cp\u003eReconstitution: Not Applicable\u003c\/p\u003e\n\n\u003cp\u003eEndotoxin: \u0026lt; 1.0 EU per μg of the protein as determined by the LAL method.\u003c\/p\u003e\n\n\u003cp\u003eCalculated MW: 14\u0026amp;59 kDa\u003c\/p\u003e\n\n\u003cp\u003eObserved MW: 18\u0026amp;70 kDa\u003c\/p\u003e\n\n\u003cp\u003eStorage: Store at \u0026lt; -20°C, stable for 6 months. Please minimize freeze-thaw cycles.\u003c\/p\u003e\n\n\u003cp\u003eShipping: This product is provided as liquid. It is shipped at frozen temperature with blue ice\/gel packs. Upon receipt, store it immediately at \u0026lt; - 20°C.\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"Elabscience","offers":[{"title":"10μg","offer_id":43072228786355,"sku":"PKSQ050064-10","price":312.2,"currency_code":"CAD","in_stock":true},{"title":"50μg","offer_id":43072228819123,"sku":"PKSQ050064-50","price":830.2,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/products\/logo_new_6e882294-f190-4cc6-9fde-6b8378ec4721.png?v=1708684711","url":"https:\/\/afsbio.com\/products\/recombinant-macaca-nemestrina-pcsk9-proprotein-convertase-9-protein-his-tag-pksq050064","provider":"AFSBio Inc.","version":"1.0","type":"link"}