{"product_id":"recombinant-mip-1β-ccl4-human-bk0137","title":"Recombinant MIP-1β\/CCL4, Human - BK0137","description":"\u003cp\u003eRecombinant MIP-1β\/CCL4, Human\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: BK0137-5, BK0137-25\u003c\/p\u003e\n\n\u003cp\u003eSizes: 5μg, 25μg\u003c\/p\u003e\n\n\u003cp\u003eSource: Escherichia coli\u003c\/p\u003e\n\n\u003cp\u003eMolecular Weight: 7.6 kDa, observed by reducing SDS-PAGE.\u003c\/p\u003e\n\n\u003cp\u003ePurity: \u0026gt; 95% as analyzed by SDS-PAGE and HPLC.\u003c\/p\u003e\n\n\u003cp\u003eBiological Activity: The EC50 value of human MIP-1 beta \/CCL4 on Caˆ2+ mobilization assay in CHO-K1\/ Gα15\/hCCR5 cells (human Gα15 and human CCR5 stably expressed in CHO-K1 cells) is less than 100 ng\/ml.\u003c\/p\u003e\n\n\u003cp\u003ePhysical Appearance: Sterile Filtered White lyophilized (freeze-dried) powder.\u003c\/p\u003e\n\n\u003cp\u003eFormulation: Lyophilized after extensive dialysis against PBS.\u003c\/p\u003e\n\n\u003cp\u003eAA Sequence: APM GSDPPTACCF SYTARKLPRN FVVDYYETSS LCSQPAVVFQ TKRSKQVCAD PSESWVQEYV YDLELN\u003c\/p\u003e\n\n\u003cp\u003eEndotoxin: \u0026lt; 0.2 EU\/μg, determined by LAL method.\u003c\/p\u003e\n\n\u003cp\u003eReconstitution: Reconstituted in ddH2O or PBS at 100 μg\/ml.\u003c\/p\u003e\n\n\u003cp\u003eStorage: Lyophilized recombinant human MIP-1 beta \/CCL4 remains stable up to 6 months at -80°C from date of receipt. Upon reconstitution, human MIP-1 beta \/CCL4 should be stable up to 1 week at 4°C or up to 2 months at -20°C.\u003c\/p\u003e\n\n\u003cp\u003eUsage: This material is offered by USA Bioworld biotech for research, laboratory or further evaluation purposes. For research use only.\u003c\/p\u003e\n\n\u003cp\u003eDescription: Macrophage inflammatory protein 1 beta (MIP-1β), also known as Chemokine (C-C motif) ligand 4(CCL4), is a small cytokine belonging to the CC chemokine family. It is a chemoattractant for natural killer cells, monocytes and a variety of other immune cells. MIP-1βis a major HIV-suppressive factor produced by CD8+ T cells. Perforin-low memory CD8+ T cells are the most common T-cells that normally synthesize MIP-1-beta in humans. MIP-1βhas been shown to interact with CCL3. It can signal through the CCR5 receptor.Recombinant MIP-1 beta\/CCL4 produced in E.coli is a single non-glycosylated polypeptide chain containing 69 amino acids. A fully biologically active molecule, rhMIP-1 beta\/CCL4 has a molecular mass of 7.6 kDa analyzed by reducing SDS-PAGE and is obtained by chromatographic techniques at GenScript.\u003c\/p\u003e","brand":"BioWorld","offers":[{"title":"5μg","offer_id":42882245066931,"sku":"BK0137-5","price":217.41,"currency_code":"CAD","in_stock":true},{"title":"25μg","offer_id":42882245099699,"sku":"BK0137-25","price":375.54,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/products\/thumbnail_d1447bac803ec9be_11-14-09-19-51_cf41ada2-7d30-4697-ac08-ad2af449ba54.jpg?v=1702049969","url":"https:\/\/afsbio.com\/products\/recombinant-mip-1%ce%b2-ccl4-human-bk0137","provider":"AFSBio Inc.","version":"1.0","type":"link"}