{"product_id":"recombinant-monoclonal-antibody-to-human-manf-343-100","title":"Recombinant Monoclonal Antibody to Human MANF - 343-100","description":"\u003cp\u003eRecombinant Monoclonal Antibody to Human MANF\u003c\/p\u003e\n\n\u003cp\u003eSize: 100 µg\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Number: 343-100\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: Human MANF\u003c\/p\u003e\n\n\u003cp\u003eImmunogen Description: Recombinant human MANF protein produced using CHO-based Icosagen Cell factory Ltd. proprietary suspension cell line. Immunogen is purified from cell culture supernatant\u003c\/p\u003e\n\n\u003cp\u003eBackground: MANF is a trophic factor for midbrain dopamine neurons in vivo. It prevents the 6-OHDA- induced degeneration of dopamine neurons in rodent models of Parkinson’s disease (Lindholm et al., 2008, Voutilainen et al., 2009). When administered after 6-OHDA-lesioning it restores the dopaminergic function and prevents degeneration of dopamine neurons in substantia nigra pars compacta\u003c\/p\u003e\n\n\u003cp\u003eUniProt ID: P55145\u003c\/p\u003e\n\n\u003cp\u003eAlternative Names: ARMET, ARP\u003c\/p\u003e\n\n\u003cp\u003eClonality: Recombinant monoclonal antibody\u003c\/p\u003e\n\n\u003cp\u003eClone: 3D10, chicken-mouse IgG2a chimeric antibody\u003c\/p\u003e\n\n\u003cp\u003eClass: mouse IgG2a\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human MANF\u003c\/p\u003e\n\n\u003cp\u003eApplication: ELISA, IF, IHC-C\u003c\/p\u003e\n\n\u003cp\u003eProtocol: ELISA 0.02 to 0.1 µg\/ml; IF 0.33 to 20 µg\/ml; IHC-C 5 µg\/ml. \u003cbr\u003e\nConformational antibody, not suitable for Western Blot application. \u003cbr\u003e\nMonoclonal antibody working titer has to be established practically for each particular antigen and assay format\u003c\/p\u003e\n\n\u003cp\u003ePurification: MabSelect affinity chromatography\u003c\/p\u003e\n\n\u003cp\u003eBuffer: PBS pH 7.4, with 0.1% sodium azide\u003c\/p\u003e\n\n\u003cp\u003eShipping: This product is shipped in non-frozen liquid form in ambient conditions\u003c\/p\u003e\n\n\u003cp\u003eStorage: Store at –20 to -70°C upon receipt. Divide antibody into aliquots prior usage. Avoid multiple freeze-thaw cycles\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"Icosagen","offers":[{"title":"Default Title","offer_id":44502416490675,"sku":"343-100","price":1195.35,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/Icosagen_e6f6057e-0727-4565-9a3f-ab939b903d53.png?v=1741969724","url":"https:\/\/afsbio.com\/products\/recombinant-monoclonal-antibody-to-human-manf-343-100","provider":"AFSBio Inc.","version":"1.0","type":"link"}