{"product_id":"recombinant-mouse-alk-4-acvr1b-protein-rp01803","title":"Recombinant Mouse ALK-4\/ACVR1B Protein - RP01803","description":"\u003cp\u003eRecombinant Mouse ALK-4\/ACVR1B Protein\u003c\/p\u003e\n\n\u003cp\u003eSizes: 10ug, 20g, 50ug, 100ug\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: RP01803-10, RP01803-20, RP01803-50, RP01803-100\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eDescription: Recombinant Mouse ALK-4\/ACVR1B Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Met1-Glu126) of mouse ALK-4\/ACVR1B (Accession #NP_031421.1) fused with hFC tag at the C-terminus.\u003c\/p\u003e\n\n\u003cp\u003eAlternate Names: Alk4; SKR2; ALK-4; ActRIB; ActR-IB; Acvrlk4; 6820432J04\u003c\/p\u003e\n\n\u003cp\u003eSWISS: Q61271\u003c\/p\u003e\n\n\u003cp\u003eGeneID: 11479\u003c\/p\u003e\n\n\u003cp\u003eSpecies: Mouse\u003c\/p\u003e\n\n\u003cp\u003ePurity: ≥ 90 % as determined by SDS-PAGE.\u003c\/p\u003e\n\n\u003cp\u003eStorage: Store at -20 ℃. Store the lyophilized protein at -20℃ to -80 ℃ up to 1 year from the date of receipt. After reconstitution, the protein solution is stable at -20℃ for 3 months, at 2-8℃ for up to 1 week.\u003c\/p\u003e\n\n\u003cp\u003eBackground: ACVR1B (Activin A Receptor, type 1B), belongs to the protein kinase superfamily, TKL Ser\/Thr protein kinase family, and TGFB receptor subfamily. ALK-4\/ACVR1B acts as a transducer of activin or activin like ligands signals. Activin binds to either ACVR2A or ACVR2B and then forms a complex with ACVR1B. The known type II activin receptors include ActRII and ActRIIB, while the main type I activin receptor in mammalian cells is ALK-4 (ActRIB). In the presence of activin, type II and type I receptors form complexes whereby the type II receptors activate ALK-4 through phosphorylation. The activated ALK-4, in turn, transduces signals downstream by phosphorylation of its effectors, such as Smads, to regulate gene expression and affect cellular phenotype. ALK-4\/ACVR1B is an important regulator of vertebrate development, with roles in mesoderm induction, primitive streak formation, gastrulation, dorsoanterior patterning, and left-right axis determination.\u003c\/p\u003e\n\n\u003cp\u003eBio-Activity: Measured by its binding ability in a functional ELISA. Immobilized Mouse TDGF1 (Catalog: RP01946) at 5 μg\/mL (100 μL\/well) can bind Mouse ALK4(Catalog: RP01803) with a linear range of 4.5-133.2 ng\/mL.\u003c\/p\u003e\n\n\u003cp\u003eSource: HEK293 cells\u003c\/p\u003e\n\n\u003cp\u003eTag: C-hFc\u003c\/p\u003e\n\n\u003cp\u003eFormulation: Lyophilized from a 0.22 μm filtered solution of PBS, pH 7.4.\u003c\/p\u003e\n\n\u003cp\u003eAntigen Sequence: MAESAGASSFFPLVVLLLAGSGGSGPRGIQALLCACTSCLQTNYTCETDGACMVSIFNLDGVEHHVRTCIPKVELVPAGKPFYCLSSEDLRNTHCCYIDFCNKIDLRVPSGHLKEPAHPSMWGPVE\u003c\/p\u003e\n\n\u003cp\u003eEndotoxin: \u0026lt; 0.01 EU\/μg of the protein by LAL method\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"ABclonal","offers":[{"title":"10ug","offer_id":45198314143923,"sku":"RP01803-10","price":182.0,"currency_code":"CAD","in_stock":true},{"title":"20ug","offer_id":45198314176691,"sku":"RP01803-20","price":252.0,"currency_code":"CAD","in_stock":true},{"title":"50ug","offer_id":45198314209459,"sku":"RP01803-50","price":280.0,"currency_code":"CAD","in_stock":true},{"title":"100ug","offer_id":45198314242227,"sku":"RP01803-100","price":420.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/download_89c210f7-8ee5-44a8-bbc5-6493c8558727.png?v=1766960494","url":"https:\/\/afsbio.com\/products\/recombinant-mouse-alk-4-acvr1b-protein-rp01803","provider":"AFSBio Inc.","version":"1.0","type":"link"}