{"product_id":"recombinant-mouse-b2m-beta-2-microglobulin-protein-his-tag-pdmm100015","title":"Recombinant Mouse B2M\/Beta-2-microglobulin Protein (His Tag) - PDMM100015","description":"\u003cp\u003eRecombinant Mouse B2M\/Beta-2-microglobulin Protein (His Tag)\u003c\/p\u003e\n\n\u003cp\u003eSizes: 20μg, 100μg\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: PDMM100015-20, PDMM100015-100\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eAbbreviation: B2M; Beta-2-microglobulin\u003c\/p\u003e\n\n\u003cp\u003eTarget Synonym: B2MG; Beta-2-Microglobulin; Beta 2 Microglobin; Beta 2 microglobulin Precursor; Beta Chain of MHC Class 1 Proteins; Beta Chain of MHC class I molecules; CDABP0092; Hdcma22p; IMD43\u003c\/p\u003e\n\n\u003cp\u003eUNIProt ID: P01887\u003c\/p\u003e\n\n\u003cp\u003eResearch Areas: Cancer\u003c\/p\u003e\n\n\u003cp\u003eTarget Species: Mouse\u003c\/p\u003e\n\n\u003cp\u003eExpression Host: HEK293 Cells\u003c\/p\u003e\n\n\u003cp\u003eFusion Tag: C-His\u003c\/p\u003e\n\n\u003cp\u003eAccession: P01887\u003c\/p\u003e\n\n\u003cp\u003eBackground: B2M, also known as β2-Microglobulin or CDABP0092, is a component of MHC class I molecules found expression in all nucleated cells (excludes red blood cells). The major function of MHC class I moleculesis is to display fragments of proteins from within the cell to T-cells and cells containing foreign proteins will be attacked. B2M (β2-Microglobulin) is a low molecular weight protein. It was demonstrated that B2M (β2-Microglobulin) was localized in the membranes of nucleated cells and was found to be associated with HL-A antigens. B2M (β2- Microglobulin) is present in free form in various body fluids and as a subunit of histocompatibility antigens on cell surfaces lateral to the α3 chain. Unlike α3, β2 has no transmembrane region. Directly above β2 lies the α1 chain, which itself is lateral to the α2. In the absence of B2M (β2 microglobulin), very limited amounts of MHC class I (classical and non-classical) molecules can be detected on the surface. In the absence of MHC class I, CD8 T cells, a subset of T cells involved in the development of acquired immunity cannot develop. Low levels of B2M (β2 microglobulin) can indicate non-progression of HIV.\u003c\/p\u003e\n\n\u003cp\u003eSequence: Met 1-Met 119\u003c\/p\u003e\n\n\u003cp\u003ePurity: \u0026gt; 95 % as determined by reducing SDS-PAGE.\u003c\/p\u003e\n\n\u003cp\u003eFormulation: Lyophilized from sterile PBS, pH 7.4.\u003cbr\u003e\nNormally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.\u003cbr\u003e\nPlease refer to the specific buffer information in the printed manual.\u003c\/p\u003e\n\n\u003cp\u003eReconstitution: Please refer to the printed manual for detailed information.\u003c\/p\u003e\n\n\u003cp\u003eEndotoxin: Please contact us for more information.\u003c\/p\u003e\n\n\u003cp\u003eCalculated MW: 10.78 kDa\u003c\/p\u003e\n\n\u003cp\u003eObserved MW: 12 kDa\u003c\/p\u003e\n\n\u003cp\u003eStorage: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at \u0026lt; -20℃ for 3 months.\u003c\/p\u003e\n\n\u003cp\u003eShipping: This product is provided as lyophilized powder which is shipped with ice packs.\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"Elabscience","offers":[{"title":"20μg","offer_id":43083631689907,"sku":"PDMM100015-20","price":264.6,"currency_code":"CAD","in_stock":true},{"title":"100μg","offer_id":43083631755443,"sku":"PDMM100015-100","price":418.6,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/products\/logo_new_1427bc33-c72d-444d-a31d-0741d65dfe7a.png?v=1708945652","url":"https:\/\/afsbio.com\/products\/recombinant-mouse-b2m-beta-2-microglobulin-protein-his-tag-pdmm100015","provider":"AFSBio Inc.","version":"1.0","type":"link"}