{"product_id":"recombinant-mouse-b7-2-cd86-protein-rp01234","title":"Recombinant Mouse B7-2\/CD86 Protein - RP01234","description":"\u003cp\u003eRecombinant Mouse B7-2\/CD86 Protein\u003c\/p\u003e\n\n\u003cp\u003eSizes: 10ug, 20g, 50ug, 100ug\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: RP01234-10, RP01234-20, RP01234-50, RP01234-100\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eDescription: Recombinant Mouse B7-2\/CD86 Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Val24-Glu245) of mouse CD86\/B7-2 (Accession #NP_062261.3) fused with a 6×His tag at the C-terminus.\u003c\/p\u003e\n\n\u003cp\u003eAlternate Names: CD86, B7-2, B70, CD28LG2, LAB72, MGC34413, CD86, CD86, B7-2, B70, CD28LG2, LAB72, MGC34413, CD86\u003c\/p\u003e\n\n\u003cp\u003eSWISS: P42082\u003c\/p\u003e\n\n\u003cp\u003eGeneID: 12524\u003c\/p\u003e\n\n\u003cp\u003eSpecies: Mouse\u003c\/p\u003e\n\n\u003cp\u003ePurity: ≥ 95 % as determined by SDS-PAGE; ≥ 90 % as determined by HPLC.\u003c\/p\u003e\n\n\u003cp\u003eStorage: Store at -20 ℃. Store the lyophilized protein at -20℃ to -80 ℃ up to 1 year from the date of receipt. After reconstitution, the protein solution is stable at -20℃ for 3 months, at 2-8℃ for up to 1 week.\u003c\/p\u003e\n\n\u003cp\u003eBackground: CD86, also known as B-lymphocyte activation antigen B7-2 (referred to as B70), is a member of the cell surface immunoglobulin superfamily. CD86 is expressed by antigen-presenting cells, and it is the ligand for two proteins at the cell surface of T cells, CD28 antigen and cytotoxic T-lymphocyte-associated protein 4. Binding of this protein with CD28 antigen is a costimulatory signal for activation of the T-cell. Binding of this protein with cytotoxic T-lymphocyte-associated protein 4 negatively regulates T-cell activation and diminishes the immune response.\u003c\/p\u003e\n\n\u003cp\u003eBio-Activity: Measured by its binding ability in a functional ELISA. Immobilized Recombinant Mouse CD86 at 2 μg\/mL (100 μL\/well) can bind Recombinant Human CTLA-4 with a linear range of 8-35 ng\/mL.\u003c\/p\u003e\n\n\u003cp\u003eSource: HEK293 cells\u003c\/p\u003e\n\n\u003cp\u003eTag: C-His\u003c\/p\u003e\n\n\u003cp\u003eFormulation: Lyophilized from a 0.22 μm filtered solution of PBS, pH 7.4. Contact us for customized product form or formulation.\u003c\/p\u003e\n\n\u003cp\u003eAntigen Sequence: VSVETQAYFNGTAYLPCPFTKAQNISLSELVVFWQDQQKLVLYEHYLGTEKLDSVNAKYLGRTSFDRNNWTLRLHNVQIKDMGSYDCFIQKKPPTGSIILQQTLTELSVIANFSEPEIKLAQNVTGNSGINLTCTSKQGHPKPKKMYFLITNSTNEYGDNMQISQDNVTELFSISNSLSLSFPDGVWHMTVVCVLETESMKISSKPLNFTQEFPSPQTYWKE\u003c\/p\u003e\n\n\u003cp\u003eEndotoxin: \u0026lt; 0.1 EU\/μg of the protein by LAL method.\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"ABclonal","offers":[{"title":"10ug","offer_id":45198317486259,"sku":"RP01234-10","price":182.0,"currency_code":"CAD","in_stock":true},{"title":"20ug","offer_id":45198317519027,"sku":"RP01234-20","price":217.0,"currency_code":"CAD","in_stock":true},{"title":"50ug","offer_id":45198317551795,"sku":"RP01234-50","price":252.0,"currency_code":"CAD","in_stock":true},{"title":"100ug","offer_id":45198317584563,"sku":"RP01234-100","price":420.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/download_49e61560-e497-4a27-be15-c9d6429caf48.png?v=1766960533","url":"https:\/\/afsbio.com\/products\/recombinant-mouse-b7-2-cd86-protein-rp01234","provider":"AFSBio Inc.","version":"1.0","type":"link"}