{"product_id":"recombinant-mouse-b7-h2-icoslg-cd275-protein-rp01548","title":"Recombinant Mouse B7-H2\/ICOSLG\/CD275 Protein - RP01548","description":"\u003cp\u003eRecombinant Mouse B7-H2\/ICOSLG\/CD275 Protein\u003c\/p\u003e\n\n\u003cp\u003eSizes: 10ug, 20g, 50ug, 100ug\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: RP01548-10, RP01548-20, RP01548-50, RP01548-100\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eDescription: Recombinant Mouse B7-H2\/ICOSLG\/CD275 Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Glu47-Lys279) of mouse B7-H2\/ICOSLG\/CD275 (Accession #NP_056605.1) fused with a 6×His tag at the C-terminus.\u003c\/p\u003e\n\n\u003cp\u003eAlternate Names: ICOSLG, B7-H2, B7H2, B7RP-1, B7RP1, CD275, GL50, ICOS-L, ICOSL, LICOS, ICOS ligand, ICOSLG\u003c\/p\u003e\n\n\u003cp\u003eSWISS: Q9JHJ8\u003c\/p\u003e\n\n\u003cp\u003eGeneID: 50723\u003c\/p\u003e\n\n\u003cp\u003eSpecies: Mouse\u003c\/p\u003e\n\n\u003cp\u003ePurity: ≥ 95 % as determined by SDS-PAGE.\u003c\/p\u003e\n\n\u003cp\u003eStorage: Store at -20 ℃. Store the lyophilized protein at -20℃ to -80 ℃ up to 1 year from the date of receipt. After reconstitution, the protein solution is stable at -20℃ for 3 months, at 2-8℃ for up to 1 week.\u003c\/p\u003e\n\n\u003cp\u003eBackground: Inducible co-stimulator ligand (ICOSL), also known as B7-H2, is a member of the B7 family of co-stimulatory molecules related to B7-1 and B7-2. It is a transmembrane glycoprotein with extracellular IgV and IgC domains and binds to ICOS on activated T cells, thus delivers a positive costimulatory signal for optimal T cell function. The structural features of ICOSL are crucial for its costimulatory function. The present study shows that ICOSL displays a marked oligomerization potential, resembling more like B7-1 than B7-2. B7-H2-dependent signaling may play an active role in a proliferative response rather than in cytokine and chemokine production. The CD28\/B7 and ICOS\/B7-H2 pathways are both critical for costimulating T cell immune responses. Deficiency in either pathway results in defective T cell activation, cytokine production, and germinal center formation.\u003c\/p\u003e\n\n\u003cp\u003eSource: HEK293 cells\u003c\/p\u003e\n\n\u003cp\u003eTag: C-His\u003c\/p\u003e\n\n\u003cp\u003eFormulation: Lyophilized from a 0.22 μm filtered solution of PBS, pH 7.4.\u003c\/p\u003e\n\n\u003cp\u003eAntigen Sequence: ETEVGAMVGSNVVLSCIDPHRRHFNLSGLYVYWQIENPEVSVTYYLPYKSPGINVDSSYKNRGHLSLDSMKQGNFSLYLKNVTPQDTQEFTCRVFMNTATELVKILEEVVRLRVAANFSTPVISTSDSSNPGQERTYTCMSKNGYPEPNLYWINTTDNSLIDTALQNNTVYLNKLGLYDVISTLRLPWTSRGDVLCCVENVALHQNITSISQAESFTGNNTKNPQETHNNELK\u003c\/p\u003e\n\n\u003cp\u003eEndotoxin: \u0026lt; 0.1 EU\/μg of the protein by LAL method.\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"ABclonal","offers":[{"title":"10ug","offer_id":45198247657651,"sku":"RP01548-10","price":182.0,"currency_code":"CAD","in_stock":true},{"title":"20ug","offer_id":45198247690419,"sku":"RP01548-20","price":252.0,"currency_code":"CAD","in_stock":true},{"title":"50ug","offer_id":45198247723187,"sku":"RP01548-50","price":280.0,"currency_code":"CAD","in_stock":true},{"title":"100ug","offer_id":45198247755955,"sku":"RP01548-100","price":420.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/download_2c85206b-f1ce-4690-882e-9e8f4df1169a.png?v=1766959694","url":"https:\/\/afsbio.com\/products\/recombinant-mouse-b7-h2-icoslg-cd275-protein-rp01548","provider":"AFSBio Inc.","version":"1.0","type":"link"}