{"product_id":"recombinant-mouse-b7-h4-vtcn1-protein-aa-29-256-fc-tag-pksm040913","title":"Recombinant Mouse B7-H4\/VTCN1 Protein (aa 29-256, Fc Tag) - PKSM040913","description":"\u003cp\u003eRecombinant Mouse B7-H4\/VTCN1 Protein (aa 29-256, Fc Tag)\u003c\/p\u003e\n\n\u003cp\u003eSize: 100μg\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Number: PKSM040913-100\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eAbbreviation: B7-H4, VTCN1\u003c\/p\u003e\n\n\u003cp\u003eTarget Synonym: V-set domain containing T-cell activation inhibitor 1, B7 homolog 4, Protein B7S1, B7-H4, VTCN1, B7h4, B7s1, B7x, BC032925\u003c\/p\u003e\n\n\u003cp\u003eUNIProt ID: Q7TSP5\u003c\/p\u003e\n\n\u003cp\u003eTarget Species: Mouse\u003c\/p\u003e\n\n\u003cp\u003eExpression Host: HEK293 Cells\u003c\/p\u003e\n\n\u003cp\u003eFusion Tag: C-hFc\u003c\/p\u003e\n\n\u003cp\u003eAccession: Q7TSP5\u003c\/p\u003e\n\n\u003cp\u003eBackground: V-set domain-containing T-cell activation inhibitor 1, also known as B7X, B7H4, B7S1, and VTCN1, is a single-pass type membrane protein belonging to the B7 family of costimulatory proteins. These proteins are expressed on the surface of antigen-presenting cells and interact with ligands on T lymphocytes. They provide costimulatory signals that regulate T cell responses. A soluble form of B7H4 has also been detected. B7X \/ VTCN1 \/ B7H4 negatively regulates T-cell-mediated immune response by inhibiting T-cell activation, proliferation, cytokine production and development of cytotoxicity. When expressed on the cell surface of tumor macrophages, B7X \/ VTCN1 \/ B7H4 plays an important role, together with regulatory T-cells(Treg), in the suppression of tumor-associated antigen-specific T-cell immunity. B7X \/ VTCN1 \/ B7H4 is also involved in promoting epithelial cell transformation. This membrane protein can be up-regulated by IL6 \/ interleukin-6 and IL10 \/ interleukin-10 and inhibited by CSF2 \/ GM-CSF and IL4 \/ interleukin-4 on antigen-presenting cells.\u003c\/p\u003e\n\n\u003cp\u003eSequence: phe 29-Ser 256\u003c\/p\u003e\n\n\u003cp\u003ePurity: \u0026gt; 95 % as determined by reducing SDS-PAGE.\u003c\/p\u003e\n\n\u003cp\u003eFormulation: Lyophilized from sterile PBS, pH 7.4\u003cbr\u003e\nNormally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.\u003cbr\u003e\nPlease refer to the specific buffer information in the printed manual.\u003c\/p\u003e\n\n\u003cp\u003eReconstitution: Please refer to the printed manual for detailed information.\u003c\/p\u003e\n\n\u003cp\u003eEndotoxin: \u0026lt; 1.0 EU per μg of the protein as determined by the LAL method.\u003c\/p\u003e\n\n\u003cp\u003eCalculated MW: 52.2 kDa\u003c\/p\u003e\n\n\u003cp\u003eObserved MW: 70-75 kDa\u003c\/p\u003e\n\n\u003cp\u003eStorage: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at \u0026lt; -20℃ for 3 months.\u003c\/p\u003e\n\n\u003cp\u003eShipping: This product is provided as lyophilized powder which is shipped with ice packs.\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"Elabscience","offers":[{"title":"100μg","offer_id":43155012550835,"sku":"PKSM040913-100","price":1024.8,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/products\/logo_new_d639d173-906f-4744-8679-c8e5ca59ff4b.png?v=1710436339","url":"https:\/\/afsbio.com\/products\/recombinant-mouse-b7-h4-vtcn1-protein-aa-29-256-fc-tag-pksm040913","provider":"AFSBio Inc.","version":"1.0","type":"link"}