{"product_id":"recombinant-mouse-b7-h5-gi24-vista-protein-rp01328","title":"Recombinant Mouse B7-H5\/Gi24\/VISTA Protein - RP01328","description":"\u003cp\u003eRecombinant Mouse B7-H5\/Gi24\/VISTA Protein\u003c\/p\u003e\n\n\u003cp\u003eSizes: 10ug, 20g, 50ug, 100ug\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: RP01328-10, RP01328-20, RP01328-50, RP01328-100\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eDescription: Recombinant Mouse B7-H5\/Gi24\/VISTA Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Phe33 - Ala191) of Mouse VISTA (Accession #NP_083008.1) fused with an 6×His tag at the C-terminus.\u003c\/p\u003e\n\n\u003cp\u003eAlternate Names: B7-H5, Gi24, VISTA, SISP1, VISTA\u003c\/p\u003e\n\n\u003cp\u003eSWISS: Q9D659\u003c\/p\u003e\n\n\u003cp\u003eGeneID: 74048\u003c\/p\u003e\n\n\u003cp\u003eSpecies: Mouse\u003c\/p\u003e\n\n\u003cp\u003ePurity: ≥ 95 % as determined by SDS-PAGE.\u003c\/p\u003e\n\n\u003cp\u003eStorage: Store at -20 ℃. Store the lyophilized protein at -20℃ to -80 ℃ up to 1 year from the date of receipt. After reconstitution, the protein solution is stable at -20℃ for 3 months, at 2-8℃ for up to 1 week.\u003c\/p\u003e\n\n\u003cp\u003eBackground: VSIR, V-Set Immunoregulatory Receptor, also known as VISTA, is an immunoregulatory receptor that inhibits the T-cell response. It may promote differentiation of embryonic stem cells, by inhibiting BMP4 signaling. VSIR, or V-set immunoregulatory receptor, could be involved in the pathogenesis of chronic rhinosinusitis with nasal polyps. V-domain Immunoglobulin Suppressor of T cell Activation (VISTA) is an inhibitory immune-checkpoint molecule that suppresses CD4+ and CD8+ T cell activation when expressed on antigen-presenting cells. VSIR is broadly expressed in the spleen, bone marrow, and other tissues. Diseases associated with VSIR include Ichthyosis, Congenital, Autosomal Recessive 6, and Monckeberg Arteriosclerosis.\u003c\/p\u003e\n\n\u003cp\u003eBio-Activity: Measured by its binding ability in a functional ELISA.Immobilized Mouse B7-H5\/VISTA (Catalog: RP01328) at 0.5 μg\/mL (100 μL\/well) can bind B7-H5\/VISTA Rabbit pAb with a linear range of 0.01-2.6 ng\/mL.\u003c\/p\u003e\n\n\u003cp\u003eSource: HEK293 cells\u003c\/p\u003e\n\n\u003cp\u003eTag: C-His\u003c\/p\u003e\n\n\u003cp\u003eFormulation: Lyophilized from a 0.22 μm filtered solution of PBS, pH 7.4.\u003c\/p\u003e\n\n\u003cp\u003eAntigen Sequence: FKVTTPYSLYVCPEGQNATLTCRILGPVSKGHDVTIYKTWYLSSRGEVQMCKEHRPIRNF TLQHLQHHGSHLKANASHDQPQKHGLELASDHHGNFSITLRNVTPRDSGLYCCLVIELKN HHPEQRFYGSMELQVQAGKGSGSTCMASNEQDSDSITAA\u003c\/p\u003e\n\n\u003cp\u003eEndotoxin: \u0026lt; 0.1 EU\/μg of the protein by LAL method.\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"ABclonal","offers":[{"title":"10ug","offer_id":45198318665907,"sku":"RP01328-10","price":196.0,"currency_code":"CAD","in_stock":true},{"title":"20ug","offer_id":45198318698675,"sku":"RP01328-20","price":266.0,"currency_code":"CAD","in_stock":true},{"title":"50ug","offer_id":45198318731443,"sku":"RP01328-50","price":280.0,"currency_code":"CAD","in_stock":true},{"title":"100ug","offer_id":45198318764211,"sku":"RP01328-100","price":448.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/download_d48ef90e-83fa-4683-9eac-7db163438815.png?v=1766960546","url":"https:\/\/afsbio.com\/products\/recombinant-mouse-b7-h5-gi24-vista-protein-rp01328","provider":"AFSBio Inc.","version":"1.0","type":"link"}