{"product_id":"recombinant-mouse-bace2-beta-secretase-2-protein-his-tagactive-pksm040382","title":"Recombinant Mouse BACE2\/Beta secretase 2 Protein (His Tag)(Active) - PKSM040382","description":"Recombinant Mouse BACE2\/Beta secretase 2 Protein (His Tag)(Active)\n\nSize: 100μg\n\nCatalogue Number: PKSM040382-100\n\nCitations, Manuals and MSDS Available upon request.\n\nAbbreviation: BACE2; Beta secretase 2\n\nTarget Symptom: 1110059C24Rik; AEPLC; AI850424; ALP56; ARP1; ASP21; BAE2; CDA13; CEAP1; DRAP\n\nTarget Species: Mouse\n\nExpression Host: HEK293 Cells\n\nApplication: Enzyme\n\nFusion Tag: C-His\n\nUNIProt ID: Q9JL18\n\nAccession: Q9JL18\n\nBackground: BACE2, also known as beta secretase 2, belongs to the peptidase A1 family. It is a protease known to be an important enzyme involved in the cellular pathways. BACE2 has been shown to interact with GGA1 and GGA2. It is the major β -secretase in vivo. BACE2 is located on chromosome 21 and may play a role in alzheimer's disease pathogenesis in down syndrome(DS). Overexpression of BACE2 by lentivirus markedly reduced amyloid β protein production in primary neurons. Despite an extra copy of the BACE2 gene in DS and the increase of its transcription, BACE2 protein levels are unchanged.\n\nActivity: Measured by its ability to cleave a fluorogenic peptide substrate Mca-KPLGL-Dpa-AR-NH2. The specific activity is \u0026gt; 50 pmoles\/min\/μg.\n\nSequence: Met1-Pro462\n\nPurity: \u0026gt; 95 % as determined by reducing SDS-PAGE.\n\nFormulation: Lyophilized from sterile PBS, pH 7.4\nNormally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.\nPlease refer to the specific buffer information in the printed manual.\n\nReconstitution: Please refer to the printed manual for detailed information.\n\nEndotoxin: \u0026lt; 1.0 EU per μg of the protein as determined by the LAL method.\n\nCalculated MW: 49.2 kDa\n\nObserved MW: 55 kDa\n\nStorage: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at \u0026lt; -20℃ for 3 months.\n\nShipping: This product is provided as lyophilized powder which is shipped with ice packs.\n\nResearch Use Only","brand":"Elabscience","offers":[{"title":"Default Title","offer_id":43104355778739,"sku":"PKSM040382-100","price":1915.2,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/products\/logo_new_8ad8e8ed-a107-4fc0-8ca5-79d9d729ce3e.png?v=1709295103","url":"https:\/\/afsbio.com\/products\/recombinant-mouse-bace2-beta-secretase-2-protein-his-tagactive-pksm040382","provider":"AFSBio Inc.","version":"1.0","type":"link"}