{"product_id":"recombinant-mouse-baffr-tnfrsf13c-c-fc-pksm041406","title":"Recombinant Mouse BAFFR\/TNFRSF13C (C-Fc) - PKSM041406","description":"\u003cp\u003eRecombinant Mouse BAFFR\/TNFRSF13C (C-Fc)\u003c\/p\u003e\n\n\u003cp\u003eSizes: 10μg, 50μg\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: PKSM041406-10, PKSM041406-50\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eAbbreviation: BAFFR; TNFRSF13C\u003c\/p\u003e\n\n\u003cp\u003eTarget Symptom: BAFF R; BAFFR; BR3; CD268; TNFRSF13C\u003c\/p\u003e\n\n\u003cp\u003eTarget Species: Mouse\u003c\/p\u003e\n\n\u003cp\u003eExpression Host: HEK293 Cells\u003c\/p\u003e\n\n\u003cp\u003eApplication: ELISA\u003c\/p\u003e\n\n\u003cp\u003eFusion Tag: C-Fc\u003c\/p\u003e\n\n\u003cp\u003eUNIProt ID: Q9D8D0\u003c\/p\u003e\n\n\u003cp\u003eAccession: Q9D8D0\u003c\/p\u003e\n\n\u003cp\u003eBackground: Tumor necrosis factor receptor superfamily, member 13C (TNFRSF13C) also known as B-cell-activating factor receptor (BAFFR) and CD268 antigen, is a member of the tumor necrosis factor receptor superfamily. BAFF promotes the survival of B cells and is essential for B cell maturation. BAFF binds to three TNF receptor superfamily members: B-cell maturation antigen (BCMA\/TNFRSF17), transmembrane activator and calcium-modulator and cyclophilin ligand interactor (TACI\/TNFRSF13B) and BAFF receptor (BAFF R\/BR3\/TNFRSF13C). These receptors are type III transmembrane proteins that lack a signal peptide. BAFF R is highly expressed in spleen, lymph node and resting B cells. It is also expressed at lower levels in activated B cell, in resting CD4+ T cells, in thymus and peripheral blood leukocytes. BAFF knockout mice lack mature B cells. Similarly, A\/WySnJ mice that are defective in BAFF-R intracellular signaling also lack mature B cells, suggesting that BAFF R is the critical receptor for BAFF during B lymphopoiesis. It has been proposed that abnormally high levels of BAFFR\/TNFRSF13C (CD268) may contribute to the pathogenesis of autoimmune diseases by enhancing the survival of autoreactive B cells.\u003c\/p\u003e\n\n\u003cp\u003eActivity: Immobilized Human BAFF-His(Cat#PKSH033865) at 10μg\/ml (100 μl\/well) can bind Human BAFFR-Fc(Cat#PKSM041406). The ED50 of Human BAFFR-Fcis 0.04ug\/ml.\u003c\/p\u003e\n\n\u003cp\u003eSequence: Ser10-Ala 71\u003c\/p\u003e\n\n\u003cp\u003ePurity: \u0026gt; 95 % as determined by reducing SDS-PAGE.\u003c\/p\u003e\n\n\u003cp\u003eFormulation: Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.\u003cbr\u003e\nNormally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.\u003cbr\u003e\nPlease refer to the specific buffer information in the printed manual.\u003c\/p\u003e\n\n\u003cp\u003eReconstitution: Please refer to the printed manual for detailed information.\u003c\/p\u003e\n\n\u003cp\u003eEndotoxin: \u0026lt; 1.0 EU per μg of the protein as determined by the LAL method.\u003c\/p\u003e\n\n\u003cp\u003eCalculated MW: 33.8 kDa\u003c\/p\u003e\n\n\u003cp\u003eObserved MW: 40-55 kDa\u003c\/p\u003e\n\n\u003cp\u003eStorage: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at \u0026lt; -20℃ for 3 months.\u003c\/p\u003e\n\n\u003cp\u003eShipping: This product is provided as lyophilized powder which is shipped with ice packs.\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"Elabscience","offers":[{"title":"10μg","offer_id":43118130135219,"sku":"PKSM041406-10","price":168.0,"currency_code":"CAD","in_stock":true},{"title":"50μg","offer_id":43118130167987,"sku":"PKSM041406-50","price":508.2,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/products\/logo_new_b74d4a14-39f5-4e56-8da1-1b944e2dc2dc.png?v=1709636764","url":"https:\/\/afsbio.com\/products\/recombinant-mouse-baffr-tnfrsf13c-c-fc-pksm041406","provider":"AFSBio Inc.","version":"1.0","type":"link"}