{"product_id":"recombinant-mouse-carbonic-anhydrase-4-ca4-protein-aa-18-277-his-tag-pksm040973","title":"Recombinant Mouse Carbonic Anhydrase 4\/CA4 Protein (aa 18-277, His Tag) - PKSM040973","description":"\u003cp\u003eRecombinant Mouse Carbonic Anhydrase 4\/CA4 Protein (aa 18-277, His Tag)\u003c\/p\u003e\n\n\u003cp\u003eSizes: 10μg, 50μg\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: PKSM040973-10, PKSM040973-50\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eAbbreviation: Carbonic Anhydrase 4; CA4\u003c\/p\u003e\n\n\u003cp\u003eTarget Synonym: CA4; CAIV; CA-IV; Car4; Carbonate dehydratase IV; carbonic anhydrase 4; carbonic anhydrase IVRP17; carbonic dehydratase IV; EC4.2.1.1; retinitis pigmentosa 17; RP17\u003c\/p\u003e\n\n\u003cp\u003eUNIProt ID: Q64444\u003c\/p\u003e\n\n\u003cp\u003eTarget Species: Mouse\u003c\/p\u003e\n\n\u003cp\u003eExpression Host: HEK293 Cells\u003c\/p\u003e\n\n\u003cp\u003eFusion Tag: C-6His\u003c\/p\u003e\n\n\u003cp\u003eAccession: Q64444\u003c\/p\u003e\n\n\u003cp\u003eBackground: Carbonic anhydrase 4(CA4) is an enzyme that belongs to the alpha-carbonic anhydrase family. CA4 consists of a signal peptide (residues1-17), an ectodomain (residues18-277) and a propeptide (residues278-305), which is removed in the mature form. it is predominantly expressed in the embryo. CA4 can catalyzes the reversible reaction of CO2+H2O=HCO3-+H+, and stimulates the sodium\/bicarbonate transporter activity of SLC4A4. Studies have shown that this protein have a role in inherited renal abnormalities of bicarbonate transport. Alpha-carbonic anhydrase family participate in avariety of biological processes, including respiration, calcification, acid-base balance, bone resorption, and the formation of aqueous humor. They show extensive diversity in tissue is attribution and in their sub cellular localization.\u003c\/p\u003e\n\n\u003cp\u003eSequence: Glu18-Ser277\u003c\/p\u003e\n\n\u003cp\u003ePurity: \u0026gt; 95 % as determined by reducing SDS-PAGE.\u003c\/p\u003e\n\n\u003cp\u003eFormulation: Supplied as a 0.2 μm filtered solution of 20mM Tris, 150mM NaCl, pH8.0.\u003cbr\u003e\nNormally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.\u003cbr\u003e\nPlease refer to the specific buffer information in the printed manual.\u003c\/p\u003e\n\n\u003cp\u003eReconstitution: Not Applicable\u003c\/p\u003e\n\n\u003cp\u003eEndotoxin: \u0026lt; 1.0 EU per μg of the protein as determined by the LAL method.\u003c\/p\u003e\n\n\u003cp\u003eCalculated MW: 30.5 kDa\u003c\/p\u003e\n\n\u003cp\u003eObserved MW: 36 kDa\u003c\/p\u003e\n\n\u003cp\u003eStorage: Store at \u0026lt; -20°C, stable for 6 months. Please minimize freeze-thaw cycles.\u003c\/p\u003e\n\n\u003cp\u003eShipping: This product is provided as liquid. It is shipped at frozen temperature with blue ice\/gel packs. Upon receipt, store it immediately at \u0026lt; - 20°C.\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"Elabscience","offers":[{"title":"10μg","offer_id":43149130006707,"sku":"PKSM040973-10","price":312.2,"currency_code":"CAD","in_stock":true},{"title":"50μg","offer_id":43149130039475,"sku":"PKSM040973-50","price":830.2,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/products\/logo_new_df9599a5-6506-4e95-ab66-5e40edae8f20.png?v=1710341190","url":"https:\/\/afsbio.com\/products\/recombinant-mouse-carbonic-anhydrase-4-ca4-protein-aa-18-277-his-tag-pksm040973","provider":"AFSBio Inc.","version":"1.0","type":"link"}