{"product_id":"recombinant-mouse-cathepsin-b-ctsb-protein-his-tag-pksm040956","title":"Recombinant Mouse Cathepsin B\/CTSB Protein (His Tag) - PKSM040956","description":"\u003cp\u003eRecombinant Mouse Cathepsin B\/CTSB Protein (His Tag)\u003c\/p\u003e\n\n\u003cp\u003eSizes: 10μg, 50μg\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: PKSM040956-10, PKSM040956-50\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eAbbreviation: Cathepsin B; CTSB\u003c\/p\u003e\n\n\u003cp\u003eTarget Synonym: Cathepsin B; Ctsb; Cathepsin B1\u003c\/p\u003e\n\n\u003cp\u003eUNIProt ID: P10605\u003c\/p\u003e\n\n\u003cp\u003eTarget Species: Mouse\u003c\/p\u003e\n\n\u003cp\u003eExpression Host: HEK293 Cells\u003c\/p\u003e\n\n\u003cp\u003eFusion Tag: C-6His\u003c\/p\u003e\n\n\u003cp\u003eAccession: P10605\u003c\/p\u003e\n\n\u003cp\u003eBackground: Cathepsin B (CatB) is an enzymatic protein belonging to the peptidase (or protease) families. It is the first described member of the family of lysosomal cysteine proteases. It is known to process a number of proteins, including pro and active caspases, prorenin and secretory leucoprotease inhibitor (SLPI). It is believed to participate in intracellular degradation and turnover of proteins. Cathepsin B may play a role in activation and inactivation of caspases, activation of renin and inactivation of SLPI, the key steps in apoptosis, angiotensin production, and progression of emphysema, respectively. Cathepsin B may also have a role in invasion and metastasis.\u003c\/p\u003e\n\n\u003cp\u003eSequence: His18-Phe339\u003c\/p\u003e\n\n\u003cp\u003ePurity: \u0026gt; 95 % as determined by reducing SDS-PAGE.\u003c\/p\u003e\n\n\u003cp\u003eFormulation: Lyophilized from a 0.2 μm filtered solution of PBS, pH7.4.\u003cbr\u003e\nNormally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.\u003cbr\u003e\nPlease refer to the specific buffer information in the printed manual.\u003c\/p\u003e\n\n\u003cp\u003eReconstitution: Please refer to the printed manual for detailed information.\u003c\/p\u003e\n\n\u003cp\u003eEndotoxin: \u0026lt; 1.0 EU per μg of the protein as determined by the LAL method.\u003c\/p\u003e\n\n\u003cp\u003eCalculated MW: 36.4 kDa\u003c\/p\u003e\n\n\u003cp\u003eObserved MW: 32-50 kDa\u003c\/p\u003e\n\n\u003cp\u003eStorage: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at \u0026lt; -20℃ for 3 months.\u003c\/p\u003e\n\n\u003cp\u003eShipping: This product is provided as lyophilized powder which is shipped with ice packs.\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"Elabscience","offers":[{"title":"10μg","offer_id":43149129318579,"sku":"PKSM040956-10","price":249.2,"currency_code":"CAD","in_stock":true},{"title":"50μg","offer_id":43149129351347,"sku":"PKSM040956-50","price":732.2,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/products\/logo_new_1081d35f-5827-4c96-a729-617f40b71386.png?v=1710341167","url":"https:\/\/afsbio.com\/products\/recombinant-mouse-cathepsin-b-ctsb-protein-his-tag-pksm040956","provider":"AFSBio Inc.","version":"1.0","type":"link"}