{"product_id":"recombinant-mouse-cathepsin-s-ctss-protein-rp01605","title":"Recombinant Mouse Cathepsin S\/CTSS Protein - RP01605","description":"\u003cp\u003eRecombinant Mouse Cathepsin S\/CTSS Protein\u003c\/p\u003e\n\n\u003cp\u003eSizes: 10ug, 20ug\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Number: RP01605-10, RP01605-20\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eDescription: Recombinant Mouse Cathepsin S\/CTSS Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Val18-Ile340) of mouse Cathepsin S\/CTSS (Accession #NP_067256.4) fused with and a 6×His tag at the C-terminus.\u003c\/p\u003e\n\n\u003cp\u003eAlternate Names: Cathepsin S; Ctss; Cats, CTSS\u003c\/p\u003e\n\n\u003cp\u003eSWISS: O70370\u003c\/p\u003e\n\n\u003cp\u003eGeneID: 13040\u003c\/p\u003e\n\n\u003cp\u003eSpecies: Mouse\u003c\/p\u003e\n\n\u003cp\u003ePurity: ≥ 95 % as determined by SDS-PAGE.\u003c\/p\u003e\n\n\u003cp\u003eStorage: Store at -20℃. Store the lyophilized protein at -20℃ to -80 ℃ up to 1 year from the date of receipt. After reconstitution, the protein solution is stable at -20℃ for 3 months, at 2-8℃ for up to 1 week.\u003c\/p\u003e\n\n\u003cp\u003eBackground: Cathepsin S (CTSS), one of the lysosomal proteinases, has many important physiological functions in the nervous system, especially in process of extracellular matrix degradation and endocellular antigen presentation. Cathepsin S is expressed in the lysosome of antigen presenting cells, primarily dendritic cells, B-cells and macrophages. Cathepsin S is most well known for its critical function in the proteolytic digestion of the invariant chain chaperone molecules, thus controlling antigen presentation to CD4+ T-cells by major histocompatibility complex (MHC) class II molecules or to NK1.1+ T-cells via CD1 molecules. Cathepsin S also appears to participate in direct processing of exogenous antigens for presentation by MHC class II to CD4+ T-cells, or in cross-presentation by MHC class I molecules to CD8+ T-cells. In addition, it has been implicated in the pathogenesis of several diseases such as Alzheimer’s disease and degenerative disorders associated with the cells of the mononuclear phagocytic system.\u003c\/p\u003e\n\n\u003cp\u003eBio-Activity: Measured by its ability to cleave the fluorogenic peptide substrate, Mca-RPKPVE- Nval-WRK(Dnp)-NH2 (RD,Catalog # ES002). The specific activity is \u0026gt;212 pmol\/ min\/μg.\u003c\/p\u003e\n\n\u003cp\u003eSource: HEK293 cells\u003c\/p\u003e\n\n\u003cp\u003eTag: C-His\u003c\/p\u003e\n\n\u003cp\u003eFormulation: Lyophilized from a 0.22 μm filtered solution of PBS, pH 7.4.\u003c\/p\u003e\n\n\u003cp\u003eAntigen Sequence: VCSVAMEQLQRDPTLDYHWDLWKKTHEKEYKDKNEEEVRRLIWEKNLKFIMIHNLEYSMGMHTYQVGMNDMGDMTNEEILCRMGALRIPRQSPKTVTFRSYSNRTLPDTVDWREKGCVTEVKYQGSCGACWAFSAVGALEGQLKLKTGKLISLSAQNLVDCSNEEKYGNKGCGGGYMTEAFQYIIDNGGIEADASYPYKATDEKCHYNSKNRAATCSRYIQLPFGDEDALKEAVATKGPVSVGIDASHSSFFFYKSGVYDDPSCTGNVNHGVLVVGYGTLDGKDYWLVKNSWGLNFGDQGYIRMARNNKNHCGIASYCSYPEI\u003c\/p\u003e\n\n\u003cp\u003eEndotoxin: \u0026lt; 0.1 EU\/μg of the protein by LAL method.\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"ABclonal","offers":[{"title":"10ug","offer_id":45198350581939,"sku":"RP01605-10","price":168.0,"currency_code":"CAD","in_stock":true},{"title":"20ug","offer_id":45198350614707,"sku":"RP01605-20","price":252.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/download_d8a08191-257b-48d8-b9c5-ffe4d27f85aa.png?v=1766960921","url":"https:\/\/afsbio.com\/products\/recombinant-mouse-cathepsin-s-ctss-protein-rp01605","provider":"AFSBio Inc.","version":"1.0","type":"link"}